Novel 3-amino-2-hydroxy acids containing protease inhibitors. Part 1 Synthesis and kinetic characterization as aminopeptidase P inhibitors
- Author
- STÖCKEL-MASCHEK, Angela1 ; STIEBITZ, Beate1 ; KOELSCH, Regine2 ; NEUBERT, Klaus1
[1] Martin -Luther -University Halle-Wittenberg, Department of Biochemistry, Institute of Biochemistry/Biotechnology, Kurt-Mothes-Str.3, 06120 Halle/Saale, Germany
[2] Martin-Luther-University Halle-Wittenberg, Medical Faculty, Institute of Physiological Chemistry, Hollystr. 1, 06114 Halle/Saale, Germany - Source
Bioorganic & medicinal chemistry. 2005, Vol 13, Num 16, pp 4806-4820, 15 p ; ref : 32 ref
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier Science, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Aminopeptidase P Bestatin Mixed-type inhibition Slow-binding inhibition
- Keyword (fr)
- Activité biologique Aminoalcool Animal Composé peptidomimétique Configuration géométrique Escherichia coli Hydroxyacide Inhibiteur enzyme Inhibiteur protease Intestin Mécanisme action Pyrrolidine dérivé Rat Synthèse chimique Ubénimex X-Pro aminopeptidase Benzènebutyrique acide(β-amino-α-hydroxy) pyrrolidide Hexanoïque acide(3-amino-2-hydroxy-5-méthyl) thiazolidide Proline analogue Thiazolidine dérivé Aminopeptidases Bactérie Enterobacteriaceae Enzyme Hydrolases Mammalia Peptidases Rodentia Vertebrata
- Keyword (en)
- Biological activity Aminoalcohol Animal Peptidomimetic compound Geometrical configuration Escherichia coli Hydroxyacid Enzyme inhibitor Protease inhibitor Gut Mechanism of action Pyrrolidine derivatives Rat Chemical synthesis Ubenimex X-Pro aminopeptidase Aminopeptidases Bacteria Enterobacteriaceae Enzyme Hydrolases Mammalia Peptidases Rodentia Vertebrata
- Keyword (es)
- Actividad biológica Aminoalcohol Animal Compuesto peptidomimético Configuración geométrica Escherichia coli Hidroxiácido Inhibidor enzima Inhibidor proteasa Intestino Mecanismo acción Rata Síntesis química Ubenimex X-Pro aminopeptidase Aminopeptidases Bacteria Enterobacteriaceae Enzima Hydrolases Mammalia Peptidases Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A02 Analytical, structural and metabolic biochemistry / 002A02E Enzymes and enzyme inhibitors / 002A02E04 Hydrolases
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02W Miscellaneous
- Discipline
- Analytical, structural and metabolic biochemistry General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16950914
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2005.05.040 
https://dx.doi.org/10.1016/j.bmc.2005.05.040
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