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N-(2-chloroethyl)-N-nitrosourea tethered to lexitropsin induces minor groove lesions at the p53 cDNA that are more cytotoxic than mutagenic

Author
INGA, A1 ; CHEN, F.-X2 ; FRONZA, G1 ; MONTI, P1 ; APRILE, A1 ; CAMPOMENOSI, P1 ; MENICHINI, P1 ; OTTAGGIO, L1 ; VIAGGI, S1 3 ; ABBONDANDOLO, A1 3 ; GOLD, B2
[1] CSTA-Mutagenesis Laboratory, National Cancer Institute (IST), 16132-Genova, Italy
[2] Eppley Institute for Research in Cancer and Allied Diseases and Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 69198-6805, United States
[3] Department of Clinical and Experimental Oncology, University of Genova, 16132 Genova, Italy
Source

Cancer research (Baltimore). 1999, Vol 59, Num 3, pp 689-695 ; ref : 41 ref

CODEN
CNREA8
ISSN
0008-5472
Scientific domain
Medical oncology; Pharmacology drugs
Publisher
American Association for Cancer Research, Philadelphia, PA
Publication country
United States
Document type
Article
Language
English
Keyword (fr)
Adduit moléculaire Agent alkylant Anticancéreux Chimiothérapie DNA Expression génique Gène TP53 Gène suppresseur tumeur In vitro Levure Mutagène Produit gène Tumorigénicité Urée(1-[2-chloroéthyl]-1-nitroso) Lexitropsine
Keyword (en)
Molecular adduct Alkylating agent Antineoplastic agent Chemotherapy DNA Gene expression TP53 Gene Tumor suppressor gene In vitro Yeast Mutagen Gene product Tumorigenicity
Keyword (es)
Producto adición molecular Agente alquilante Anticanceroso Quimioterapia DNA Expresión genética Gen TP53 Gen supresor tumor In vitro Levadura Mutágeno Producto gene Tumorigenicidad
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B04 Tumors / 002B04E Carcinogenesis, carcinogens and anticarcinogens / 002B04E02 Chemical agents

Discipline
Tumours
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
1696072

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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