Structure-activity relationship studies of salubrinal lead to its active biotinylated derivative
- Author
- KAI LONG1 ; BOYCE, Michael2 ; HE LIN1 ; JUNYING YUAN2 ; DAWEI MA1
[1] State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, China
[2] Department of Cell Biology, Harvard Medical School, Boston, MA 02115, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 17, pp 3849-3852, 4 p ; ref : 10 ref
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Apoptosis Inhibitor of eIF2α dephosphorylation Synthesis
- Keyword (fr)
- Apoptose Biotinylation Carboxamide Chlore composé organique Déphosphorylation Facteur initiation eIF2 In vitro Inhibiteur Initiation traduction Lignée cellulaire Molécule petite Neurone Protection Quinoléine dérivé Rat Relation structure activité Réticulum endoplasmique Stress Surrénale Synthèse chimique Cinnamide dérivé Lignée PC12 Salubrinal Mammalia Rodentia Vertebrata
- Keyword (en)
- Apoptosis Biotinylation Carboxamide Organic chlorine compounds Dephosphorylation Initiation factor eIF2 In vitro Inhibitor Translation initiation Cell line Small molecule Neuron Protection Quinoline derivatives Rat Structure activity relation Endoplasmic reticulum Stress Adrenal glands Chemical synthesis Mammalia Rodentia Vertebrata
- Keyword (es)
- Apoptosis Biotinilacion Carboxamida Desfosforilización Factor iniciación eIF2 In vitro Inhibidor Iniciación traducción Línea celular Molécula pequeña Neurona Protección Quinolina derivado Rata Relación estructura actividad Retículo endoplásmico Estrés Suprarrenal Síntesis química Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02W Miscellaneous
- Discipline
- General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16984213
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2005.05.120 
https://dx.doi.org/10.1016/j.bmcl.2005.05.120
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