Synthesis and structure-activity relationships of a new series of retinoid-related biphenyl-4-ylacrylic acids endowed with antiproliferative and proapoptotic activity
- Author
- CINCINELLI, Raffaella1 ; DALLAVALLE, Sabrina1 ; VESCI, Loredana2 ; CARMINATI, Paolo2 ; ZUCO, Valentina4 ; ZANCHI, Chiara4 ; ZUNINO, Franco4 ; NANNEI, Raffaella1 ; CARELLA, Serena1 ; DE ZANI, Daniele1 ; MERLINI, Lucio1 ; PENCO, Sergio2 ; GARATTINI, Enrico3 ; GIANNINI, Giuseppe2 ; PISANO, Claudio2
[1] Dipartimento di Scienze Molecolari Agroalimentari, Università di Milano, Via Celoria 2, 20133 Milano, Italy
[2] Sigma-tau, R&D, Pomezia, Italy
[3] Laboratory of Molecular Biology, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
[4] Unità di Farmacologia Antitumorale Preclinica, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano, Italy - Source
Journal of medicinal chemistry (Print). 2005, Vol 48, Num 15, pp 4931-4946, 16 p ; ref : 38 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Acide carboxylique Affinité Anticancéreux Apoptose Benzène dérivé Biphényle dérivé Cellule tumorale Composé tricyclique Composé vinylique Homme In vitro Leucémie promyélocytaire Ligand Lignée cellulaire Mort cellulaire Ovaire Phénols Relation structure activité Récepteur acide rétinoïque RAR Rétinoïde Synthèse chimique Adamantane dérivé Biphényle-4-acrylique acide(3p-adamantyl-4p-hydroxy) Lignée IGROV1 Lignée NB4
- Keyword (en)
- Carboxylic acid Affinity Antineoplastic agent Apoptosis Benzene derivatives Biphenyl derivatives Tumor cell Tricyclic compound Vinylic compound Human In vitro Promyelocytic leukemia Ligand Cell line Cell death Ovary Phenols Structure activity relation RAR retinoic acid receptor Retinoid Chemical synthesis
- Keyword (es)
- Acido carboxílico Afinidad Anticanceroso Apoptosis Benceno derivado Bifenilo derivado Célula tumoral Compuesto tricíclico Compuesto vinílico Hombre In vitro Leucemia promielocítica Ligando Línea celular Muerte celular Ovario Fenoles Relación estructura actividad Receptor ácido retinoico RAR Retinoide Síntesis química
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16989190
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm049440h 
https://dx.doi.org/10.1021/jm049440h
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