Structure-activity relationships of 1-alkyl-5-(3,4-dichlorophenyl)-5-{2-[3-(substituted)-1-azetidinyl]-ethyl}-2-piperidones. Part 2: Improving oral absorption
- Author
- MIDDLETON, Donald S1 ; MACKENZIE, A. Roderick1 ; NEWMAN, Sandra D1 ; CORLESS, Martin1 ; WARREN, Andrew1 ; MARCHINGTON, Allan P1 ; JONES, Barry2
[1] Department of Discovery Chemistry, Pfizer Global Research and Development, Sandwich, Kent CT13 9NJ, United Kingdom
[2] Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Sandwich, Kent CT13 9NJ, United Kingdom - Source
Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 17, pp 3957-3961, 5 p ; ref : 13 ref
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Absorption Animal Azétidine dérivé Chlore composé organique Côlon Fluor composé organique Homme In vitro Lignée cellulaire Pharmacocinétique Pipéridine dérivé Rat Relation structure activité Résistance hydrolyse Voie orale Lignée CACO2 Pipéridin-2-one dérivé Pipéridin-2-one(4-[3,4-dichlorophényl]-1-[4,4-difluorocyclohexylméthyl]-4-[2-(3-[4-fluoropipéridino]azétidino)éthyl]) Mammalia Rodentia Vertebrata
- Keyword (en)
- Absorption Animal Azetidine derivatives Organic chlorine compounds Colon Organic fluorine compounds Human In vitro Cell line Pharmacokinetics Piperidine derivatives Rat Structure activity relation Hydrolysis resistance Oral administration Mammalia Rodentia Vertebrata
- Keyword (es)
- Absorción Animal Colón Hombre In vitro Línea celular Farmacocinética Piperidina derivado Rata Relación estructura actividad Resistencia hidrólisis Vía oral Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09F Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16989338
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2005.05.134 
https://dx.doi.org/10.1016/j.bmcl.2005.05.134
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