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Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice

Author
XING XIAN YU1 ; MURRAY, Susan F1 ; BHANOT, Sanjay1 ; PANDEY, Sanjay K1 ; BOOTEN, Sheri L1 ; DINGJIU BAO1 ; SONG, Xiu-Zhen1 ; KELLY, Susan1 ; SONGYUAN CHEN1 ; MCKAY, Robert1 ; MONIA, Brett P1
[1] Department of Antisense Drug Discovery, Isis Pharmaceuticals, Inc, Carlsbad, CA, United States
Source

Hepatology (Baltimore, Md.). 2005, Vol 42, Num 2, pp 362-371, 10 p ; ref : 34 ref

CODEN
HPTLD9
ISSN
0270-9139
Scientific domain
Gastroenterology
Publisher
Wiley, Hoboken, NJ
Publication country
United States
Document type
Article
Language
English
Keyword (fr)
Acyltransferases Animal Coenzyme A Etat nutritionnel Foie Glucose Glycérol Hyperlipémie Insuline Lipide Matière grasse Microstructure Obésité Oligonucléotide antisens Pathogénie Poids corporel RNA messager Régime alimentaire Souris Stéatose hépatique Traitement Triglycéride X Syndrome Appareil circulatoire pathologie Dyslipémie Endocrinopathie Enzyme Foie pathologie Mammalia Métabolisme pathologie Rodentia Transferases Trouble nutrition Vertebrata
Keyword (en)
Acyltransferases Animal Coenzyme A Nutritional status Liver Glucose Glycerol Hyperlipemia Insulin Lipids Fat Microstructure Obesity Antisense oligonucleotide Pathogenesis Body weight Messenger RNA Diet Mouse Fatty liver Treatment Triglyceride X Syndrome Cardiovascular disease Dyslipemia Endocrinopathy Enzyme Hepatic disease Mammalia Metabolic diseases Rodentia Transferases Nutrition disorder Vertebrata
Keyword (es)
Acyltransferases Animal Coenzima A Estado nutricional Hígado Glucosa Glicerol Hiperlipemia Insulina Lípido Materia grasa Microestructura Obesidad Oligonucleótido antisentido Patogenia Peso corporal RNA mensajero Régimen alimentario Ratón Hígado graso Tratamiento Triglicérido X Síndrome Aparato circulatorio patología Dislipemia Endocrinopatía Enzima Hígado patología Mammalia Metabolismo patología Rodentia Transferases Trastorno nutricíon Vertebrata
Classification
Pascal
002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A17 Vertebrates: digestive system / 002A17F Liver. Bile. Biliary tracts

Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B22 Metabolic diseases / 002B22A Disorders of blood lipids. Hyperlipoproteinemia

Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B22 Metabolic diseases / 002B22B Obesity

Discipline
Metabolic diseases Vertebrates : digestive and urinary system
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
16994199

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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