Synthesis and preliminary biological evaluation of new anti-tubulin agents containing different benzoheterocycles
- Author
- ROMAGNOLI, Romeo1 ; BARALDI, Pier Giovanni1 ; BALZARINI, Jan3 ; HAMEL, Ernest4 ; JUNG, M. Katherine2 ; IACONINOTO, Maria Antonietta1 ; CARRION, Maria Dora1 ; REMUSAT, Vincent1 ; PRETI, Delia1 ; TABRIZI, Mojgan Aghazadeh1 ; FRANCESCA, Fruttarolo1 ; DE CLERCQ, Erik3
[1] Dipartimento di Scienze Farmaceutiche, Universitá di Ferrara, Via Fossato di Mortara 17/19, 44100 Ferrara, Italy
[2] Science Applications International Corporation-Frederick Inc., National Cancer Institute cit Frederick, National Institutes of Health, Frederick, MD 21702, United States
[3] Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Minderbroedersstraat 10, 3000 Leuven, Belgium
[4] Screening Technologies Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD21702, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 18, pp 4048-4052, 5 p
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Anti-tubulin agents Benzoheterocycles Combretastatin- A4
- Keyword (fr)
- Activité biologique Alcaloïde Anticancéreux Antimitotique Antitubuline Benzofurane dérivé Cellule tumorale Composé aromatique Glande mammaire In vitro Indole dérivé Leucémie Lignée L1210 Lignée cellulaire Mécanisme action Souris Synthèse chimique Benzo[b]thiophène dérivé Benzo[b]thiophène(3-amino-2-[3,4,5-triméthoxybenzoyl]) Combretastatine A4 dérivé Lignée FM3A Mammalia Rodentia Vertebrata
- Keyword (en)
- Biological activity Alkaloid Antineoplastic agent Antimitotic Antitubulin Benzofuran derivatives Tumor cell Aromatic compound Mammary gland In vitro Indole derivatives Leukemia L1210 cell line Cell line Mechanism of action Mouse Chemical synthesis Mammalia Rodentia Vertebrata
- Keyword (es)
- Actividad biológica Alcaloide Anticanceroso Antimitótico Antitubulina Célula tumoral Compuesto aromático Glándula mamaria In vitro Indol derivado Leucemia Célula L1210 Línea celular Mecanismo acción Ratón Síntesis química Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 17018575
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2005.06.022 
https://dx.doi.org/10.1016/j.bmcl.2005.06.022
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