Analysis of structure-activity relationships for the 'B-region' of N-(4-t-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl ]- thiourea analogues as TRPV1 antagonists
- Author
- LEE, Jeewoo1 ; JIN, Mi-Kyoung1 ; KIM, Sung-Eun1 ; SUH, Young-Ger1 ; LEE, Yong-Sil1 ; KIM, Young-Ho2 ; HA, Hee-Jin2 ; TOTH, Attila3 ; PEARCE, Larry V3 ; TRAN, Richard3 ; SZABO, Tamas3 ; WELTER, Jacqueline D3 ; KANG, Sang-Uk1 ; LUNDBERG, Daniel J3 ; YUN WANG3 ; LAZAR, Jozsef3 ; PAVLYUKOVETS, Vladimir A3 ; MORGAN, Matthew A3 ; BLUMBERG, Peter M3 ; SU YEON KIM1 ; LEE, Jiyoun1 ; SHIN, Myoungyoup1 ; HWANG, Jaemin1 ; CHO, Sookhyun1 ; CHOI, Yeon-Sil1 ; CHOI, Hyun-Kyung1
[1] Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, Korea, Republic of
[2] Digitalbiotech, Ansan, Kyounggi-Do 425-839, Korea, Republic of
[3] Laboratory of Cellular Carcinogenesis and Tumor Promotion, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 18, pp 4143-4150, 8 p
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Capsaicin Molecular modeling Resiniferatoxin TRPV1 antagonist Vanilloid Receptor 1 antagonist
- Keyword (fr)
- Antagoniste Benzène dérivé Capsaïcine In vitro Modèle moléculaire Modélisation Prédiction Relation structure activité Récepteur vanilloïde VR1 Thiourées Récepteur vanilloïde TRPV1 Résinifératoxine Thiourée(1-[4-t-butylbenzyl]-3-[4-(mésylamino)benzyl])
- Keyword (en)
- Antagonist Benzene derivatives Capsaicin In vitro Molecular model Modeling Prediction Structure activity relation VR1 vanilloid receptor Thioureas TRPV1 vanilloid receptor
- Keyword (es)
- Antagonista Benceno derivado Capsicina In vitro Modelo molecular Modelización Predicción Relación estructura actividad Receptor vaniloide VR1 Tioureas
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09G Miscellaneous
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 17018593
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2005.06.006 
https://dx.doi.org/10.1016/j.bmcl.2005.06.006
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