Novel 17β-substituted conformationally constrained neurosteroids that modulate GABAA receptors
- Author
- SOULI, Charikleia1 ; AVLONITIS, Nicolaos1 ; PAPADOPOULOS, Manthos1 ; CALOGEROPOULOU, Theodora1 ; TSOTINIS, Andrew2 ; MAKSAY, Gabor3 ; BIRO, Timea3 ; POLITI, Aggeliki1 ; MAVROMOUSTAKOS, Thomas1 ; MAKRIYANNIS, Alexandros4 ; REIS, Heribert1
[1] Institute of Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, 11635 Athens, Greece
[2] Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Athens, Panepistimioupoli-Zografou, 15771 Athens, Greece
[3] Department of Molecular Pharmacology, Institute of Biomolecular Chemistry, Chemical Research Center, Hungarian Academy of Sciences, POB 17, 1525, Budapest, Hungary
[4] Center for Drug Discovery, Northeastern University, 360 Huntington Avenue, 116 Mugar Hall, Boston, Massachusetts 02115, United States - Source
Journal of medicinal chemistry (Print). 2005, Vol 48, Num 16, pp 5203-5214, 12 p ; ref : 37 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Affinité Alcool secondaire Analyse conformationnelle Animal Composé acétylénique Composé allénique Encombrement stérique Encéphale Fixation biologique In vitro Ligand Neurostéroïde Rat Relation structure activité Rigidité moléculaire Récepteur gabaergique A Régulation allostérique Stéroïde Synthèse chimique Système nerveux central 5α-Androstan-3-ol(17β-[1-hydroxybuta-2,3-diényl]) Mammalia Rodentia Vertebrata
- Keyword (en)
- Affinity Secondary alcohol Conformational analysis Animal Acetylenic compound Allenic compound Steric hindrance Encephalon Biological fixation In vitro Ligand Neurosteroid Rat Structure activity relation Molecular rigidity Gabaergic receptor A Allosteric regulation Steroid Chemical synthesis Central nervous system Mammalia Rodentia Vertebrata
- Keyword (es)
- Afinidad Alcohol secundario Análisis conformacional Animal Compuesto acetilénico Compuesto alénico Embarazo estérico Encéfalo Fijación biológica In vitro Ligando Neurosteroido Rata Relación estructura actividad Rigidez molecular Receptor gabaminérgico A Regulación alostérica Esteroide Síntesis química Sistema nervioso central Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09D Gabaergic and benzodiazepinic system
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 17021601
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm050271q 
https://dx.doi.org/10.1021/jm050271q
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