5-substituted 4-anilinoquinazolines as potent, selective and orally active inhibitors of erbB2 receptor tyrosine kinase
- Author
- BALLARD, Peter1 ; BRADBURY, Robert H1 ; HENNEQUIN, Laurent F. A2 ; MARK HICKINSON, D1 ; JOHNSON, Paul D1 ; KETTLE, Jason G1 ; KLINOWSKA, Teresa1 ; MORGENTIN, Remy2 ; OGILVIE, Donald J1 ; OLIVIER, Annie2
[1] Cancer and Infection Research, AstraZeneca, Mereside, Alderley Park, Macclesfield SK10 4TG, United Kingdom
[2] AstraZeneca, Centre de Recherches, Z.I. la Pompelle, BPI050, 51689 Reims, France - Source
Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 19, pp 4226-4229, 4 p
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Anilinoquinazoline Receptor tyrosine kinase erbB2
- Keyword (fr)
- Amine aromatique Aniline dérivé Animal Cellule tumorale Croissance Epiderme Gène erbB2 Gène onc Homme Inhibiteur enzyme Inhibition Lignée KB Lignée cellulaire Modèle Optimisation Pharmacocinétique Protein-tyrosine kinase Quinazoline dérivé Récepteur biologique Récepteur facteur croissance épiderme Souris Synthèse chimique Sélectivité Transduction signal Voie orale Inhibiteur erbB2 Quinazoline(4-[3-chloro-4-(2-pyridylméthoxy)anilino]-5-[1-méthyl-4-pipéridyloxy]) Enzyme Mammalia Rodentia Transferases Vertebrata
- Keyword (en)
- Aromatic amine Aniline derivatives Animal Tumor cell Growth Epidermis erbB2 Gene Onc gene Human Enzyme inhibitor Inhibition KB cell line Cell line Models Optimization Pharmacokinetics Protein-tyrosine kinase Quinazoline derivatives Biological receptor Epidermal growth factor receptor Mouse Chemical synthesis Selectivity Signal transduction Oral administration Enzyme Mammalia Rodentia Transferases Vertebrata
- Keyword (es)
- Amina aromática Anilina derivado Animal Célula tumoral Crecimiento Epidermis Gen erbB2 Gen onc Hombre Inhibidor enzima Inhibición Célula KB Línea celular Modelo Optimización Farmacocinética Protein-tyrosine kinase Receptor biológico Receptor factor crecimiento epidermi Ratón Síntesis química Selectividad Transducción señal Vía oral Enzima Mammalia Rodentia Transferases Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 17039205
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2005.06.068 
https://dx.doi.org/10.1016/j.bmcl.2005.06.068
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