Antitumor activity and distribution of pyrroloiminoquinones in the sponge genus Zyzzya
- Author
- DIJOUX, Marie-Geneviève1 ; SCHNABEL, Peter C2 ; CARDELLINA, John H1 ; HALLOCK, Yali F1 ; BOSWELL, Jamie L1 ; JOHNSON, Tanya R1 ; WILSON, Jennifer A1 ; IRELAND, Chris M3 ; VAN SOEST, Rob4 ; BOYD, Michael R1 ; BARROWS, Louis R2
[1] Laboratory of Drug Discovery Research and Development, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute-Frederick Cancer Research & Development Center, Building 1052-Room 121, Frederick, MD 21702-1201, United States
[2] Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, UT 84112, United States
[3] Department of Medicinal Chemistry, College of Pharmacy, University of Utah, 308 Skaggs Hall, Salt Lake City, UT 84112, United States
[4] Zoölogisch Museum of the University of Amsterdam, Mauritskade 61, PO Box 94766, 1090 GT Amsterdam, Netherlands - Source
Bioorganic & medicinal chemistry. 2005, Vol 13, Num 21, pp 6035-6044, 10 p ; ref : 30 ref
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier Science, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Antitumor DNA damage DNA intercalation Pyrroloiminoquinone Topoisomerase II Zyzzya
- Keyword (fr)
- Activité biologique Agent intercalant Anticancéreux Cellule tumorale Clivage Cytotoxicité DNA topoisomerase (ATP-hydrolysing) DNA Homme In vitro Lignée cellulaire Milieu marin Mécanisme action Origine animale Pharmacognosie Porifera Quinone imine Scission Pyrrolo[4,3,2-de]quinoléin-8-one dérivé Pyrroloiminoquinone Pyrroloquinoléine Zyzzya Australie Enzyme Invertebrata Isomerases Océanie
- Keyword (en)
- Biological activity Intercalating agent Antineoplastic agent Tumor cell Cleavage Cytotoxicity DNA topoisomerase (ATP-hydrolysing) DNA Human In vitro Cell line Marine environment Mechanism of action Animal origin Pharmacognosy Porifera Quinone imine Scission Australia Enzyme Invertebrata Isomerases Oceania
- Keyword (es)
- Actividad biológica Agente intercalante Anticanceroso Célula tumoral Clivaje Citotoxicidad DNA topoisomerase (ATP-hydrolysing) DNA Hombre In vitro Línea celular Medio marino Mecanismo acción Origen animal Farmacognosia Porifera Quinona imina Escisión Australia Enzima Invertebrata Isomerases Oceania
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02A General pharmacology / 002B02A04 Pharmacognosy. Homeopathy. Health food
- Discipline
- General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 17136363
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2005.06.019 
https://dx.doi.org/10.1016/j.bmc.2005.06.019
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