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Monocarboxylic-based phosphotyrosyl mimetics in the design of GRB2 SH2 domain inhibitors

Author
BURKE, T. R1 ; LUO, J2 ; YAO, Z.-J1 ; YANG GAO1 ; HE ZHAO1 ; MILNE, G. W. A1 2 ; RIBO GUO2 ; VOIGT, J. H1 ; KING, C. R2 ; DAJUN YANG2
[1] Laboratory of Medicinal Chemistry, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Building 37, Room 5C06, Bethesda, MD 20892, United States
[2] Lombardi Cancer Center, Georgetown University Medical Center, Washington, DC, United States
Source

Bioorganic & medicinal chemistry letters (Print). 1999, Vol 9, Num 3, pp 347-352 ; ref : 26 ref

ISSN
0960-894X
Scientific domain
Biochemistry, molecular biology, biophysics; Pharmacology drugs
Publisher
Elsevier, Oxford
Publication country
United Kingdom
Document type
Article
Language
English
Keyword (fr)
Activité biologique Anticancéreux Asparagine Cellule tumorale Glande mammaire In vitro Inhibiteur Peptide Récepteur biologique Récepteur facteur croissance Synthèse chimique Transduction signal Tripeptide Tumeur maligne Domaine SH2 Phénylalanine(4-[carboxy difluoro méthyl]) Phénylalanine(4-[carboxyméthoxy]) Phénylalanine(4-carboxyméthyl)
Keyword (en)
Biological activity Antineoplastic agent Asparagine Tumor cell Mammary gland In vitro Inhibitor Peptides Biological receptor Growth factor receptor Chemical synthesis Signal transduction Tripeptide Malignant tumor SH2 Domain
Keyword (es)
Actividad biológica Anticanceroso Asparagina Célula tumoral Glándula mamaria In vitro Inhibidor Péptido Receptor biológico Receptor factor crecimiento Síntesis química Transducción señal Tripéptido Tumor maligno
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects

Discipline
Pharmacological treatments
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
1715319

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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