Inhibitors of phenylethanolamine N-methyltransferase devoid of α2-adrenoceptor affinity
- Author
- GRUNEWALD, Gary L1 ; JIAN LU1 ; CRISCIONE, Kevin R1 ; OKORO, Cosmas O1
[1] Department of Medicinal Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, KS 66045, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 23, pp 5319-5323, 5 p
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Blood-brain barrier Inhibitor Phenylethanolamine-N-methyltransferase Selectivity α2- Adrenoceptor
- Keyword (fr)
- Affinité Barrière hématoencéphalique Composé aromatique Fluor Composé organique Halogène Composé organique In vitro Inhibiteur enzyme Isoquinoléine dérivé Phenylethanolamine N-methyltransferase Relation structure activité Récepteur α2-adrénergique Synthèse chimique Sélectivité Isoquinoléine(7-halogéno-1,2,3,4-tétrahydro-3-trifluorométhyl) Enzyme Methyltransferases Transferases
- Keyword (en)
- Affinity Blood brain barrier Aromatic compound Fluorine Organic compounds Halogen Organic compounds In vitro Enzyme inhibitor Isoquinoline derivatives Phenylethanolamine N-methyltransferase Structure activity relation α2-Adrenergic receptor Chemical synthesis Selectivity Enzyme Methyltransferases Transferases
- Keyword (es)
- Afinidad Barrera hematoencefálica Compuesto aromático Fluor Compuesto orgánico Halógeno Compuesto orgánico In vitro Inhibidor enzima Isoquinoleína Phenylethanolamine N-methyltransferase Relación estructura actividad Receptor α2-adrenérgico Síntesis química Selectividad Enzima Methyltransferases Transferases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09G Miscellaneous
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 17209431
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2005.08.033 
https://dx.doi.org/10.1016/j.bmcl.2005.08.033
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