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N-methyl-5-tert-butyltryptamine : A novel, highly potent 5-HT1D receptor agonist

Author
XU, Y.-C1 ; SCHAUS, J. M1 ; WALKER, C1 ; KRUSHINSKI, J1 ; ADHAM, N2 ; ZGOMBICK, J. M2 ; LIANG, S. X1 ; KOHLMAN, D. T1 ; AUDIA, J. E1
[1] Discovery Chemistry Research, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285, United States
[2] Synaptic Pharmaceutical Corporation, 215 College Road, Paramus, New Jersey 07652, United States
Source

Journal of medicinal chemistry (Print). 1999, Vol 42, Num 3, pp 526-531 ; ref : 22 ref

CODEN
JMCMAR
ISSN
0022-2623
Scientific domain
Pharmacology drugs
Publisher
American Chemical Society, Washington, DC
Publication country
United States
Document type
Article
Language
English
Keyword (fr)
Affinité Agoniste Amine Antimigraineux Composé aromatique Composé bicyclique Homme Hétérocycle azote In vitro Relation structure activité Récepteur sérotoninergique 5-HT1 Synthèse chimique Indole(5-alkyl-3-[2-aminoéthyl]) Indole(5-t-butyl-3-[2-(méthylamino)éthyl]) Récepteur sérotoninergique 5-HT1D Tryptamine dérivé
Keyword (en)
Affinity Agonist Amine Antimigrainous agent Aromatic compound Bicyclic compound Human Nitrogen heterocycle In vitro Structure activity relation 5-HT1 Serotonine receptor Chemical synthesis
Keyword (es)
Afinidad Agonista Amina Agente antimigrañoso Compuesto aromático Compuesto bicíclico Hombre Heterociclo nitrógeno In vitro Relación estructura actividad Receptor serotoninérgico 5-HT1 Síntesis química
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09C Serotoninergic system

Discipline
Pharmacological treatments
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
1722448

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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