Scaffold hopping with molecular field points : Identification of a cholecystokinin-2 (CCK2) receptor pharmacophore and its use in the design of a prototypical series of pyrrole- and imidazole-based CCK2antagonists
- Author
- LOW, Caroline M. R1 ; BUCK, Ildiko M1 ; COOKE, Tracey1 ; CUSHNIR, Julia R1 ; KALINDJIAN, S. Barret1 ; KOTECHA, Atul1 ; PETHER, Michael J1 ; SHANKLEY, Nigel P1 ; VINTER, J. G2 ; WRIGHT, Laurence1
[1] James Black Foundation, 68 Half Moon Lane, London, SE24 9JE, United Kingdom
[2] Cresset BioMolecular Discovery Ltd., Spirella Building, Bridge Road, Letchworth, Herts, SG6 4ET, United Kingdom - Source
Journal of medicinal chemistry (Print). 2005, Vol 48, Num 22, pp 6790-6802, 13 p ; ref : 51 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Acide carboxylique Affinité Antagoniste Benzène dérivé Composé non peptide Cycle 5 chaînons Hétérocycle azote Imidazole dérivé In vitro Modèle moléculaire Modélisation Naphtalène dérivé Pyrrole dérivé Relation structure activité Récepteur cholécystokinine CCKB Synthèse chimique Sélectivité Benzoïque acide3-[([2-cycloheptyl-5-(2-naphtyl)pyrrol-3-yl]carbonyl)amino] Benzoïque acide3-[([5-cycloheptyl-2-(2-naphtyl)imidazol-4-yl]carbonyl)amino] Cycloheptane dérivé Imidazole-4-carboxamide dérivé Pyrrole-3-carboxamide dérivé
- Keyword (en)
- Carboxylic acid Affinity Antagonist Benzene derivatives Non peptide compound Five membered ring Nitrogen heterocycle Imidazole derivatives In vitro Molecular model Modeling Naphthalene derivatives Pyrrole derivatives Structure activity relation CCKB cholecystokinin receptor Chemical synthesis Selectivity
- Keyword (es)
- Acido carboxílico Afinidad Antagonista Benceno derivado Compuesto no péptido Ciclo 5 eslabones Heterociclo nitrógeno Imidazol derivado In vitro Modelo molecular Modelización Naftaleno derivado Pirrol derivado Relación estructura actividad Receptor colecistoquinina CCKB Síntesis química Selectividad
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09F Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 17233489
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm049069y 
https://dx.doi.org/10.1021/jm049069y
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