Simultaneous determination of metformin and gliclazide in human plasma by liquid chromatography-tandem mass spectrometry : application to a bioequivalence study of two formulations in healthy volunteers
- Author
- ZHONG, Guo-Ping1 ; BI, Hui-Chang1 ; SHUFENG ZHOU2 ; XIAO CHEN3 ; MIN HUANG1
[1] Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University, 74 Zhongshan Road II, Guangzhou 510080, China
[2] Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore
[3] Department of Pharmacy, the First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Road, Guangzhou 510080, China - Source
Journal of mass spectrometry. 2005, Vol 40, Num 11, pp 1462-1471, 10 p ; ref : 36 ref
- ISSN
- 1076-5174
- Scientific domain
- Biochemistry, molecular biology, biophysics; Analytical chemistry; Organic chemistry
- Publisher
- Wiley, Chichester
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- bioavailability bioequivalence gliclazide liquid chromatography/tandem mass spectrometry metformin pharmacokinetics
- Keyword (fr)
- Analyse chimique Analyse quantitative Biodisponibilité Bioéquivalence Chromatographie HPLC Chromatographie phase inverse Formulation Gliclazide Homme Hypoglycémiant Liquide biologique Mesure simultanée Metformine Méthode couplée Normal Pharmacocinétique Plasma sanguin Sang Spectrométrie masse tandem Validation Voie orale Volontaire LC MS MS Biguanides Sulfonylurées
- Keyword (en)
- Chemical analysis Quantitative analysis Bioavailability Bioequivalence HPLC chromatography Reversed phase chromatography Formulation Gliclazide Human Hypoglycemic agent Biological fluid Simultaneous measurement Metformin Coupled method Normal Pharmacokinetics Blood plasma Blood Mass spectrometry MS/MS Validation Oral administration Volunteer Biguanides Sulfonylureas
- Keyword (es)
- Análisis químico Análisis cuantitativo Biodisponibilidad Bioequivalencia Cromatografía HPLC Cromatografía fase inversa Formulación Gliclazida Hombre Hipoglicemiante Líquido biológico Medición simultánea Metformina Método acoplado Normal Farmacocinética Plasma sanguíneo Sangre Espectrometría masa en tándem Validación Vía oral Voluntario Biguanidas Sulfonilureas
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02A General pharmacology / 002B02A02 Analysis
- Discipline
- General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 17239314
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1002/jms.907 
https://dx.doi.org/10.1002/jms.907
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