Introduction of a cis-prolyl mimic in position 7 of the peptide hormone oxytocin does not result in antagonistic activity
- Author
- WITTELSBERGER, Angela1 ; PATINY, Luc1 ; SLANINOVA, Jirina2 ; BARBERIS, Claude3 ; MUTTER, Manfred1
[1] Institute of Chemical Sciences and Engineering (ISIC), Swiss Federal Institute of Technology, EPFL-BCH, 1015 Lausanne, Switzerland
[2] Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, 16610 Prague, Czech Republic
[3] INSERM U469, 141 Rue de la Cardonille, 34094 Montpellier, France - Source
Journal of medicinal chemistry (Print). 2005, Vol 48, Num 21, pp 6553-6562, 10 p ; ref : 51 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Affinité Agoniste Animal Conformation Homme Hormone peptide Hétérocycle soufre azote In vitro Ocytocine Peptide cyclique Peptide soufre Phase solide Rat Relation structure activité Récepteur hormonal Récepteur ocytocine Spectrométrie RMN Synthèse chimique Synthèse peptidique Séquence impulsion Utérus Thiazolidine-4-carboxylique acide dérivé Mammalia Rodentia Vertebrata
- Keyword (en)
- Affinity Agonist Animal Conformation Human Peptide hormone Sulfur nitrogen heterocycle In vitro Oxytocin Cyclic peptides Sulfur peptide Solid phase Rat Structure activity relation Hormonal receptor Oxytocin receptor NMR spectrometry Chemical synthesis Peptide synthesis Pulse sequence Uterus Mammalia Rodentia Vertebrata
- Keyword (es)
- Afinidad Agonista Animal Conformación Hombre Hormona péptido Heterociclo azufre nitrógeno In vitro Ocitocina Péptido cíclico Péptido azufre Fase sólida Rata Relación estructura actividad Receptor hormonal Receptor ocitocina Espectrometría RMN Síntesis química Síntesis peptídica Secuencia impulsos Utero Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02O Hormones. Endocrine system
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 17241728
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm049205z 
https://dx.doi.org/10.1021/jm049205z
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