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The small molecule tyrosine kinase inhibitor AMN107 inhibits TEL-PDGFRβ and FIP1L1-PDGFRα in vitro and in vivo

STOVER, Elizabeth H; JING CHEN; FABBRO, Doriano; MANLEY, Paul W; GRIFFIN, James D; GARY GILLILAND, D; LEE, Benjamin H; COOLS, Jan; MCDOWELL, Elizabeth; ADELSPERGER, Jennifer; CULLEN, Dana; COBURN, Allison; MOORE, Sandra A; OKABE, Rachel
Dana- Farber Cancer Institute, Boston, MA, United States
Department of Genetics, Harvard Medical School, Boston, MA, United States
Department of Human Genetics, University of Leuven-Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium
Department of Pathology, Brigham and Women's Hospital, Boston, MA, United States
Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston; MA, United States
Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, United States
Novartis Institutes for Biomedical Research, Basel, Switzerland
Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, United States

Blood. 2005, Vol 106, Num 9, pp 3206-3213, 8 p ; ref : 40 ref

Scientific domain
Medical oncology; Hematology
The Americain Society of Hematology, Washington, DC
Publication country
United States
Document type
Keyword (fr)
Animal Anticancéreux Gène hybride Homme In vitro In vivo Myéloprolifératif syndrome Protéine fusion Souris Traitement AMN 107 Gène ETV6 Gène FIP1L1 Inhibiteur tyrosine kinase Récepteur PDGFRB Hémopathie Mammalia Rodentia Vertebrata
Keyword (en)
Animal Antineoplastic agent Hybrid gene Human In vitro In vivo Myeloproliferative syndrome Fusion protein Mouse Treatment Tyrosine kinase inhibitor Platelet derived growth factor receptor beta Hemopathy Mammalia Rodentia Vertebrata
Keyword (es)
Animal Anticanceroso Gen híbrido Hombre In vitro In vivo Mieloproliferativo síndrome Proteína fusionada Ratón Tratamiento Hemopatía Mammalia Rodentia Vertebrata
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R02 Chemotherapy

002 Biological and medical sciences / 002B Medical sciences / 002B19 Hematologic and hematopoietic diseases / 002B19B Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis

Blood diseases Pharmacological treatments
INIST identifier

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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