Inhibitors of epidermal growth factor receptor tyrosine kinase : Novel C-5 substituted anilinoquinazolines designed to target the ribose pocket
- Author
- BALLARD, Peter1 ; BRADBURY, Robert H1 ; PASS, Martin1 ; OGILVIE, Donald J1 ; OLIVIER, Annie2 ; WARIN, Nicolas2 ; WILLIAMS, Emma J1 ; HARRIS, Craig S2 ; HENNEQUIN, Laurent F. A2 ; HICKINSON, Mark1 ; JOHNSON, Paul D1 ; KETTLE, Jason G1 ; KLINOWSKA, Teresa1 ; LEACH, Andrew G1 ; MORGENTIN, Remy2
[1] AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire, SK10 4TG, United Kingdom
[2] AstraZeneca, Centre de Recherches, Z.I. la Pompelle, BP1050, 51689 Reims, France - Source
Bioorganic & medicinal chemistry letters (Print). 2006, Vol 16, Num 6, pp 1633-1637, 5 p
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- EGF Inhibitor Kinase Quinazoline
- Keyword (fr)
- Amine aromatique Aniline dérivé Animal Anticancéreux Benzène dérivé Biodisponibilité Cellule tumorale Chimiothérapie Complexe enzyme inhibiteur Composé aromatique Composé bicyclique Cytotoxicité Côlon Epiderme Homme Hétérocycle azote In vitro In vivo Inhibiteur enzyme Lignée KB Lignée cellulaire Modèle moléculaire Modélisation Pharmacocinétique Pipéridine dérivé Protein-tyrosine kinase Prédiction Quinazoline dérivé Rat Relation structure activité Récepteur facteur croissance épiderme Site actif Souris Traitement Transduction signal Tumeur maligne Voie intraveineuse Voie orale Lignée LOVO Quinazoline(4-[3-chloro-4-fluoroanilino]-7-méthoxy-5-[1-méthylpipéridin-4-yloxy]) Chlore Composé organique Enzyme Fluor Composé organique Mammalia Rodentia Transferases Vertebrata
- Keyword (en)
- Aromatic amine Aniline derivatives Animal Antineoplastic agent Benzene derivatives Bioavailability Tumor cell Chemotherapy Inhibitor enzyme complex Aromatic compound Bicyclic compound Cytotoxicity Colon Epidermis Human Nitrogen heterocycle In vitro In vivo Enzyme inhibitor KB cell line Cell line Molecular model Modeling Pharmacokinetics Piperidine derivatives Protein-tyrosine kinase Prediction Quinazoline derivatives Rat Structure activity relation Epidermal growth factor receptor Active site Mouse Treatment Signal transduction Malignant tumor Intravenous administration Oral administration Chlorine Organic compounds Enzyme Fluorine Organic compounds Mammalia Rodentia Transferases Vertebrata
- Keyword (es)
- Amina aromática Anilina derivado Animal Anticanceroso Benceno derivado Biodisponibilidad Célula tumoral Quimioterapia Complejo enzima inhibidor Compuesto aromático Compuesto bicíclico Citotoxicidad Colón Epidermis Hombre Heterociclo nitrógeno In vitro In vivo Inhibidor enzima Célula KB Línea celular Modelo molecular Modelización Farmacocinética Piperidina derivado Protein-tyrosine kinase Predicción Rata Relación estructura actividad Receptor factor crecimiento epidermi Lugar activo Ratón Tratamiento Transducción señal Tumor maligno Vía intravenosa Vía oral Cloro Compuesto orgánico Enzima Fluor Compuesto orgánico Mammalia Rodentia Transferases Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 17556854
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2005.12.028 
https://dx.doi.org/10.1016/j.bmcl.2005.12.028
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