Identification of novel parasitic cysteine protease inhibitors by use of virtual screening. 2. The available chemical directory

Autor

DESAI, Prashant V¹ ; PATNY, Akshay¹ ; GUT, Jiri² ; ROSENTHAL, Philip J² ; TEKWANI, Babu³ ; SRIVASTAVA, Anuradha³ ; AVERY, Mitchell^{1 3 4}
[1] Department of Medicinal Chemistry, School of Pharmacy, P.O. Box 1848, University of Mississippi University, Mississippi 38677-1848, United States
[2] Department of Medicine, San Francisco General Hospital, University of California, San Francisco, Box 0811, San Francisco. California 94143, United States
[3] National Center for Natural Products Research, School of Pharmacy, P.O. Box 1848, University of Mississippi, University, Mississippi 38677-1848, United States
[4] Department of Chemistry and Biochemistry, P.O. Box 1848, University of Mississippi, University, Mississippi 38677-1848, United States

Fuente

Journal of medicinal chemistry (Print). 2006, Vol 49, Num 5, pp 1576-1584, 9 p ; ref : 48 ref

CODEN

JMCMAR

ISSN

0022-2623

Campo Científico

Pharmacology drugs

Editor

American Chemical Society, Washington, DC

País de la publicación

United States

Tipo de documento

Article

Idioma

English

Palabra clave (fr)

Antipaludique Antiparasitaire Antiprotozoaire Chimiothèque Composé non peptide Conformation Cysteine endopeptidases Halogène composé organique Imidazole dérivé In vitro Inhibiteur enzyme Leishmania donovani Modèle moléculaire Modélisation Plasmodium falciparum Pyridine dérivé Pyrimidine dérivé Relation structure activité Criblage virtuel Inhibiteur cysteine protease Apicomplexa Enzyme Hydrolases Kinetoplastida Peptidases Protozoa

Palabra clave (in)

Antimalarial Parasiticide Antiprotozoal agent Chemical compound library Non peptide compound Conformation Cysteine endopeptidases Organic halogen compounds Imidazole derivatives In vitro Enzyme inhibitor Leishmania donovani Molecular model Modeling Plasmodium falciparum Pyridine derivatives Pyrimidine derivatives Structure activity relation Virtual screening Apicomplexa Enzyme Hydrolases Kinetoplastida Peptidases Protozoa

Palabra clave (es)

Antipalúdico Antiparasitario Antiprotozoario Quimioteca Compuesto no péptido Conformación Cysteine endopeptidases Imidazol derivado In vitro Inhibidor enzima Leishmania donovani Modelo molecular Modelización Plasmodium falciparum Piridina derivado Pirimidina derivado Relación estructura actividad Cribado virtual Apicomplexa Enzima Hydrolases Kinetoplastida Peptidases Protozoa

Clasificación

Pascal

002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S06 Antiparasitic agents

Disciplina

Pharmacological treatments

Procedencia

Inist-CNRS

Base de datos

PASCAL

Identificador INIST

17595045

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