Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells
- Author
- OTA, H1 2 ; TOKUNAGA, E1 3 ; CHANG, K1 ; HIKASA, M1 ; LIJIMA, K2 ; ETO, M2 ; KOZAKI, K2 ; AKISHITA, M2 ; OUCHI, Y2 ; KANEKI, M1 3
[1] Deportment of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States
[2] Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, Bunkyo, Tokyo, Japan
[3] Shriners Hospital for Children, Boston, MA, United States - Source
Oncogene (Basingstoke). 2006, Vol 25, Num 2, pp 176-185, 10 p ; ref : 67 ref
- ISSN
- 0950-9232
- Scientific domain
- Cell biology, histology; Medical oncology; Genetics
- Publisher
- Nature Publishing, Basingstoke
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Akt/PKB MAPK Ras Sirti Sirtinol cellular senescence
- Keyword (fr)
- Akt protein kinase Carcinogenèse Croissance Homme Inhibiteur Mitogen-activated protein kinase Sénescence Tumeur maligne Enzyme
- Keyword (en)
- Akt protein kinase Carcinogenesis Growth Human Inhibitor Mitogen-activated protein kinase Senescence Malignant tumor Enzyme
- Keyword (es)
- Akt protein kinase Carcinogénesis Crecimiento Hombre Inhibidor Mitogen-activated protein kinase Senescencia Tumor maligno Enzima
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A04 Molecular and cellular biology / 002A04H Cell physiology / 002A04H04 Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes
- Discipline
- Molecular and cell biology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 17642925
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/sj.onc.1209049 
https://dx.doi.org/10.1038/sj.onc.1209049
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