Psoralen analogues : synthesis, inhibitory activity of growth of human tumor cell lines and computational studies

Author

OLIVEIRA, A. M. A. G¹ ; RAPOSO, M. Manuela M¹ ; OLIVEIRA-CAMPOS, A. M. F¹ ; MACHADO, A. E. H² ; PUAPAIROJ, Prapawadee^{3 4} ; PEDRO, Madalena³ ; NASCIMENTO, Maria Sao José^{3 5} ; PORTELA, César³ ; AFONSO, Carlos^{3 6} ; PINTO, Madalena^{3 6}
[1] Centro de Química, Universidade do Minho, Campus de Gualtar, 4710 Braga, Portugal
[2] Laboratório de Fotoquímica/GFQM, Instituto de Quimica, Universidade Fédéral de Uberlândia, P.O. Box 593, Uberlândia, 38408-100, Minas Gérais, Brazil
[3] Faculdade de Farmácia, Centro de Estudos de Quimica Orgânica, Fitoquimica e Farmacologia da Universidade do Porto (CEQOFFUP), Rua Aníbal Cunha, 167, 4050-047 Porto, Portugal
[4] Department of Pharmacology, Faculty of Medicine, Khonkhaen University, Khonkhaen, Thailand
[5] Laboratório de Microhiologia, Faculdade de Farmácia da Universidade do Porto, 4050-047 Porto, Portugal
[6] Laboratório de Química Orgânica, Faculdade de Farmácia da Universidade do Porto, 4050-047 Porto, Portugal

Source

European journal of medicinal chemistry. 2006, Vol 41, Num 3, pp 367-372, 6 p ; ref : 14 ref

CODEN

EJMCA5

ISSN

0223-5234

Scientific domain

Organic chemistry; Pharmacology drugs

Publisher

Elsevier, Oxford

Publication country

United Kingdom

Document type

Article

Language

English

Author keyword

Antitumor Benzopsoralens Computational studies Furocoumarins

Keyword (fr)

Anticancéreux Cellule tumorale Composé aromatique Composé tétracyclique Coumarine dérivé Cytotoxicité Glande mammaire Gliome Homme Hétérocycle oxygène In vitro Isomère position Lactone Lignée cellulaire Modèle 3 dimensions Modèle moléculaire Modèle électrostatique Modélisation Poumon Psoralène dérivé Relation structure activité Synthèse chimique Système nerveux central Benzofurocoumarine dérivé Lignée MCF7 Lignée NCIH460 Lignée SF268

Keyword (en)

Antineoplastic agent Tumor cell Aromatic compound Tetracyclic compound Coumarine derivatives Cytotoxicity Mammary gland Glioma Human Oxygen heterocycle In vitro Position isomer Lactone Cell line Three dimensional model Molecular model Electrostatic model Modeling Lung Psoralen derivatives Structure activity relation Chemical synthesis Central nervous system

Keyword (es)

Anticanceroso Célula tumoral Compuesto aromático Compuesto tetracíclico Citotoxicidad Glándula mamaria Glioma Hombre Heterociclo oxígeno In vitro Isómero posición Lactona Línea celular Modelo 3 dimensiones Modelo molecular Modelo electrostático Modelización Pulmón Relación estructura actividad Síntesis química Sistema nervioso central

Classification

Pascal

002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects

Discipline

Pharmacological treatments

Origin

Inist-CNRS

Database

PASCAL

INIST identifier

17696103

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS