Comparative structure-activity relationships of benztropine analogues at the dopamine transporter and histamine H1 receptors
- Author
- KULKAMI, Santosh S1 ; KOPAJTIC, Theresa A2 ; KATZ, Jonathan L2 ; NEWMAN, Amy Hauck1
[1] Medicinal Chemistry Section, Intramural Research Program, National Institute on Drug Abuse, NIH, 5500, Nathan Shock Drive, Baltimore, MD 21224, United States
[2] Psychobiology Section, Intramural Research Program, National Institute on Drug Abuse, NIH, 5500, Nathan Shock Drive, Baltimore, MD 21224, United States - Source
Bioorganic & medicinal chemistry. 2006, Vol 14, Num 11, pp 3625-3634, 10 p ; ref : 40 ref
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier Science, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Benztropines Cocaine Dopamine transporter Histamine H1 receptor Molecular modeling Pharmacophore
- Keyword (fr)
- Alcaloïde Amine biogène Analyse conformationnelle Benzatropine Catécholamine Cocaïne Composé aromatique Etude comparative Fixation biologique Interaction moléculaire Modèle moléculaire Modélisation Neurotransmetteur Protéine transport Relation structure activité Récepteur histaminergique H1 Stéréosélectivité Sélectivité Transport membranaire Tropane dérivé 8-Azabicyclo[3.2.1]octane dérivé Transporteur dopamine Tropane-2-carboxylique acide(3-[4,4p-difluorobenzhydryloxy]) ester méthyle
- Keyword (en)
- Alkaloid Biogenic amine Conformational analysis Benzatropine Catecholamine Cocaine Aromatic compound Comparative study Biological fixation Molecular interaction Molecular model Modeling Neurotransmitter Carrier protein Structure activity relation H1 Histamine receptor Stereoselectivity Selectivity Membrane transport Tropane derivatives
- Keyword (es)
- Alcaloide Amina biógena Análisis conformacional Benzatropina Catecolamina Cocaína Compuesto aromático Estudio comparativo Fijación biológica Interacción molecular Modelo molecular Modelización Neurotransmisor Proteína transportador Relación estructura actividad Receptor histaminérgico H1 Estereoselectividad Selectividad Transporte membranal
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09B Cholinergic system
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02J Histamine and antagonists. Allergy
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 17698178
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2006.01.017 
https://dx.doi.org/10.1016/j.bmc.2006.01.017
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