Preparation of yuanhuacine and relative daphne diterpene esters from Daphne genkwa and structure-activity relationship of potent inhibitory activity against DNA topoisomerase I
- Author
- SHIXUAN ZHANG1 ; XIAONA LI1 ; FENGHONG ZHANG1 ; PUWEN YANG1 ; XIUJUAN GAO1 ; QILING SONG1
[1] State Key Laboratory of Fine Chemicals, Dalian University of Technology, Zhongshan Road 158-90, Dalian 116012, China - Source
Bioorganic & medicinal chemistry. 2006, Vol 14, Num 11, pp 3888-3895, 8 p ; ref : 18 ref
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier Science, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Daphne diterpene esters Daphne genkwa Inhibitory activity against DNA topoisomerase I Yuanhuacine
- Keyword (fr)
- Analyse structurale Anticancéreux DNA topoisomerase Diterpène Electrophorèse gel In vitro Inhibiteur enzyme Isolement Médecine traditionnelle Origine végétale Orthoester Pharmacognosie Plante médicinale Relation structure activité Spectrométrie RMN Synthèse chimique Terpénoïde Thymelaeaceae Daphnane dérivé Daphne genkwa Médecine traditionnelle chinoise Yuanhuacine Yuanhuagine Yuanhuajine Chine Angiospermae Dicotyledones Enzyme Isomerases Spermatophyta Asie
- Keyword (en)
- Structural analysis Antineoplastic agent DNA topoisomerase Diterpene Gel electrophoresis In vitro Enzyme inhibitor Isolation Folk medicine Plant origin Orthoester Pharmacognosy Medicinal plant Structure activity relation NMR spectrometry Chemical synthesis Terpenoid Thymelaeaceae China Angiospermae Dicotyledones Enzyme Isomerases Spermatophyta Asia
- Keyword (es)
- Análisis estructural Anticanceroso DNA topoisomerase Diterpeno Electroforesis gel In vitro Inhibidor enzima Aislamiento Medicina tradicional Origen vegetal Ortoester Farmacognosia Planta medicinal Relación estructura actividad Espectrometría RMN Síntesis química Terpenoide Thymelaeaceae China Angiospermae Dicotyledones Enzima Isomerases Spermatophyta Asia
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02A General pharmacology / 002B02A04 Pharmacognosy. Homeopathy. Health food
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- General pharmacology Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 17698205
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2006.01.055 
https://dx.doi.org/10.1016/j.bmc.2006.01.055
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