Design and synthesis of 1-indol-1-yl-propan-2-ones as inhibitors of human cytosolic phospholipase A2α
- Author
- LUDWIG, Joachim1 ; BOVENS, Stefanie1 ; BRAUCH, Carsten1 ; ELFRINGHOFF, Alwine Schulze1 ; LEHR, Matthias1
[1] Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, Hittorfstrasse 58-62, 48149 Münster, Germany - Source
Journal of medicinal chemistry (Print). 2006, Vol 49, Num 8, pp 2611-2620, 10 p ; ref : 35 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Benzène dérivé Composé aromatique Composé bicyclique Cytosol Cétoéther Homme Hétérocycle azote Inhibiteur enzyme Phospholipase A2 Relation structure activité Synthèse chimique Indole-3,5-dicarboxylique acide(1-[3-(4-décyloxyphénoxy)acétonyl]) 3 ester méthyle Carboxylic ester hydrolases Enzyme Esterases Fluor Composé organique Hydrolases
- Keyword (en)
- Benzene derivatives Aromatic compound Bicyclic compound Cytosol Ketoether Human Nitrogen heterocycle Enzyme inhibitor Phospholipase A2 Structure activity relation Chemical synthesis Carboxylic ester hydrolases Enzyme Esterases Fluorine Organic compounds Hydrolases
- Keyword (es)
- Benceno derivado Compuesto aromático Compuesto bicíclico Citosol Cetoéter Hombre Heterociclo nitrógeno Inhibidor enzima Phospholipase A2 Relación estructura actividad Síntesis química Carboxylic ester hydrolases Enzima Esterases Fluor Compuesto orgánico Hydrolases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02L Bones, joints and connective tissue. Antiinflammatory agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 17708011
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm051243a 
https://dx.doi.org/10.1021/jm051243a
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