Synthesis and pharmacological evaluation of novel 9- and 10-substituted cytisine derivatives. nicotinic ligands of enhanced subtype selectivity
- Author
- CHELLAPPAN, Sheela K1 ; YINGXIAN XIAO2 ; TUECKMANTEL, Werner3 ; KELLAR, Kenneth J2 ; KOZIKOWSKI, Alan P1
[1] Drug Discovery Program, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612, United States
[2] Department of Pharmacology, Georgetown University, 3900 Reservoir Road, NW, Washington, D.C. 20057, United States
[3] Acenta Discovery Inc, 9030 S. Rita Road, Suite 300, Tucson, Arizona 85747, United States - Source
Journal of medicinal chemistry (Print). 2006, Vol 49, Num 9, pp 2673-2676, 4 p ; ref : 37 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Affinité Agoniste Alcaloïde Composé tricyclique Enantiomère(-) Enantiosélectivité Hétérocycle azote angulaire In vitro Lactame Racémique Relation structure activité Récepteur cholinergique Récepteur nicotinique Soustype Synthèse chimique Sélectivité 1,5-Méthanopyrido[1,2-a]diazocin-8-one dérivé Cytisine Méthanopyridodiazocine
- Keyword (en)
- Affinity Agonist Alkaloid Tricyclic compound Enantiomer(-) Enantioselectivity Angular nitrogen heterocycle In vitro Lactam Racemic Structure activity relation Cholinergic receptor Nicotinic receptor Subtype Chemical synthesis Selectivity
- Keyword (es)
- Afinidad Agonista Alcaloide Compuesto tricíclico Enantiómero(-) Enantioselectividad Heterociclo nitrógeno angular In vitro Lactamo Racémico Relación estructura actividad Receptor colinérgico Receptor nicotínico Subtipo Síntesis química Selectividad
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09B Cholinergic system
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 17741437
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm051196m 
https://dx.doi.org/10.1021/jm051196m
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