Site-saturated mutagenesis of histidine 234 of Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase demonstrates dual functions in cyclization and rearrangement reactions
- Author
- WU, Tung-Kung1 ; LIU, Yuan-Ting1 ; CHANG, Cheng-Hsiang1 ; YU, Mei-Ting1 ; WANG, Hisng-Ju1
[1] Department of Biological Science and Technology, National Chiao Tung University, 300, Hsin-Chu, Taiwan, Province of China - Source
Journal of the American Chemical Society. 2006, Vol 128, Num 19, pp 6414-6419, 6 p ; ref : 26 ref
- CODEN
- JACSAT
- ISSN
- 0002-7863
- Scientific domain
- Biochemistry, molecular biology, biophysics; Chemistry; Organic chemistry; Atomic molecular physics
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Activité catalytique Catalyse enzymatique Cyclisation Lanosterol synthase Mutagenèse dirigée Mécanisme réaction Réaction catalytique Saccharomyces cerevisiae Spectrométrie RMN Transposition chimique 2,3-Epoxysqualène Ascomycetes Enzyme Fungi Intramolecular transferases Isomerases Thallophyta
- Keyword (en)
- Catalyst activity Enzymatic catalysis Cyclization Lanosterol synthase Site directed mutagenesis Reaction mechanism Catalytic reaction Saccharomyces cerevisiae NMR spectrometry Chemical rearrangement Ascomycetes Enzyme Fungi Intramolecular transferases Isomerases Thallophyta
- Keyword (es)
- Actividad catalítica Catálisis enzimática Ciclización Lanosterol synthase Mutagénesis dirigida Mecanismo reacción Reacción catalítica Saccharomyces cerevisiae Espectrometría RMN Transposición química Ascomycetes Enzima Fungi Intramolecular transferases Isomerases Thallophyta
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A03 Molecular biophysics / 002A03E Physical chemistry in biology / 002A03E01 Mechanisms. Catalysis. Electron transfer. Models
- Discipline
- Molecular biophysics
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 17767618
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/ja058782p 
https://dx.doi.org/10.1021/ja058782p
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