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The structure of dasatinib (BMS-354825) bound to activated ABL kinase domain elucidates its inhibitory activity against imatinib-resistant ABL mutants

Author
TOKARSKI, John S1 ; NEWITT, John A1 ; DIANLIN XIE1 ; YAQUN ZHANG1 ; KLEI, Herbert E1 ; CHANG, Chieh Ying J1 ; CHENG, Janet D1 ; WITTEKIND, Michael1 ; KIEFER, Susan E1 ; KISH, Kevin1 ; LEE, Francis Y. F1 ; BORZILLERRI, Robert1 ; LOMBARDO, Louis J1
[1] Bristol-Mvers Squibb Company, Pharmaceutical Research Institute, Princeton, New Jersey, United States
Source

Cancer research (Baltimore). 2006, Vol 66, Num 11, pp 5790-5797, 8 p ; ref : 44 ref

CODEN
CNREA8
ISSN
0008-5472
Scientific domain
Medical oncology; Pharmacology drugs
Publisher
American Association for Cancer Research, Philadelphia, PA
Publication country
United States
Document type
Article
Language
English
Keyword (fr)
Activité biologique Anticancéreux Imatinib Inhibiteur enzyme Kinase Mutation Protein-tyrosine kinase Résistance Structure Gène abl Inhibiteur tyrosine kinase Enzyme Transferases
Keyword (en)
Biological activity Antineoplastic agent Imatinib Enzyme inhibitor Kinase Mutation Protein-tyrosine kinase Resistance Structure Enzyme Transferases
Keyword (es)
Actividad biológica Anticanceroso Imatinib Inhibidor enzima Kinase Mutación Protein-tyrosine kinase Resistencia Estructura Enzima Transferases
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents

Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B04 Tumors

Discipline
Pharmacological treatments Tumours
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
17834701

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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