Inhibition of lysosomal cysteine proteases by a series of Au(I) complexes : A detailed mechanistic investigation
- Author
- GUNATILLEKE, Shamila S1 ; BARRIOS, Amy M1
[1] Department of Chemistry, University of Southern California, Los Angeles, California 90089, United States - Source
Journal of medicinal chemistry (Print). 2006, Vol 49, Num 13, pp 3933-3937, 5 p ; ref : 42 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Antiinflammatoire Antirhumatismal Auranofine Cathepsin Cinétique Complexe arylthio Coordinat organique In vitro Inhibiteur enzyme Inhibition compétitive Lysosome Mécanisme action Or I Complexe Phosphine tertiaire Relation structure activité Synthèse chimique Thioglycoside Thiolate 1-Thioglucopyranosato(tétra-O-acétyl) Antiarthritique Benzènethiolate(4-nitro) Benzènethiolate Triarylphosphine Triéthylphosphine Enzyme Hydrolases Métal monovalent Complexe Métal transition Complexe Peptidases Phosphore Composé organique
- Keyword (en)
- Antiinflammatory agent Antirheumatic agent Auranofin Cathepsin Kinetics Arylthio complex Organic ligand In vitro Enzyme inhibitor Competitive inhibition Lysosome Mechanism of action Gold I Complexes Tertiary phosphine Structure activity relation Chemical synthesis Thioglycoside Thiolate Enzyme Hydrolases Univalent metal Complexes Transition metal Complexes Peptidases Phosphorus Organic compounds
- Keyword (es)
- Antiinflamatorio Antireumático Auranofina Cathepsin Cinética Complejo ariltio Ligando orgánico In vitro Inhibidor enzima Inhibición competitiva Lisosoma Mecanismo acción Oro I Complejo Fosfina terciaria Relación estructura actividad Síntesis química Tioglicósido Tiolato Enzima Hydrolases Metal monovalente Complejo Metal transición Complejo Peptidases Fósforo Compuesto orgánico
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02L Bones, joints and connective tissue. Antiinflammatory agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 17913642
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm060158f 
https://dx.doi.org/10.1021/jm060158f
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