Minimizing polymorphic metabolism in drug discovery : Evaluation of the utility of in vitro methods for predicting pharmacokinetic consequences associated with CYP2D6 metabolism
- Author
- GIBBS, John P1 ; HYLAND, Ruth1 ; YOUDIM, Kuresh1
[1] Pharmacokinetics, Dynamics, and Metabolism, Pfizer, Groton, Connecticut and Sandwich, United Kingdom - Source
Drug metabolism and disposition. 2006, Vol 34, Num 9, pp 1516-1522, 7 p ; ref : 41 ref
- CODEN
- DMDSAI
- ISSN
- 0090-9556
- Scientific domain
- Pharmacology drugs
- Publisher
- American Society for Pharmacology and Experimental Therapeutics, Bethesda, MD
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Cytochrome P450 Evaluation In vitro Isozyme Médicament Métabolisme Méthode Pharmacocinétique Polymorphisme Prédiction Recherche développement Cytochrome P4502D6 Enzyme
- Keyword (en)
- Cytochrome P450 Evaluation In vitro Isozyme Drug Metabolism Method Pharmacokinetics Polymorphism Prediction Research and development Enzyme
- Keyword (es)
- Citocromo P450 Evaluación In vitro Isozima Medicamento Metabolismo Método Farmacocinética Polimorfismo Predicción Investigación desarrollo Enzima
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments
- Discipline
- General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 18057938
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1124/dmd.105.008714 
https://dx.doi.org/10.1124/dmd.105.008714
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