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Random chemistry as a new tool for the generation of small-compound libraries

Author
KAPKOVA, Petra1 ; HELLER, Eberhard1 ; KUGELMANN, Eva1 ; FABER, Johan2 ; BRINGMANN, Gerhard2 ; KESSLER, Ulrich3 ; FOLKERS, Gerd3 ; HOLZGRABE, Ulrike1
[1] Institute of Pharmacy and Food Chemistry, University of Würzburg, Würzburg, Germany
[2] Institute of Organic Chemistry, University of Würzburg, Würzburg, Germany
[3] Institute of Pharmaceutical Sciences, ETH Zürich, Zürich, Switzerland
Source

Archiv der Pharmazie (Weinheim). 2006, Vol 339, Num 9, pp 489-497, 9 p ; ref : 26 ref

CODEN
ARPMAS
ISSN
0365-6233
Scientific domain
Organic chemistry; Pharmacology drugs
Publisher
Wiley-VCH, Weinheim
Publication country
Germany
Document type
Article
Language
English
Author keyword
Bioassay-guided fractionation r;-Irradiation / Random chemistry / Re-combinatorial chemistry
Keyword (fr)
Acridine dérivé Cation organique Chimie combinatoire Chimiothèque Chromatographie HPLC Criblage Irradiation gamma Isoquinoléine dérivé Molécule petite Méthode couplée Pyridinium composé Pyrimidine dérivé Radiochimie Réaction radicalaire Spectrométrie masse Synthèse chimique Tacrine Test activité Acetylcholinesterase Anticholinestérasique Carboxylic ester hydrolases Enzyme Esterases Hydrolases Inhibiteur enzyme
Keyword (en)
Acridine derivatives Organic cation Combinatorial chemistry Chemical compound library HPLC chromatography Screening Gamma irradiation Isoquinoline derivatives Small molecule Coupled method Pyridinium compounds Pyrimidine derivatives Radiochemistry Free radical reaction Mass spectrometry Chemical synthesis Tacrine Screening test Acetylcholinesterase Anticholinesterase agent Carboxylic ester hydrolases Enzyme Esterases Hydrolases Enzyme inhibitor
Keyword (es)
Catión orgánico Química combinatoria Quimioteca Cromatografía HPLC Cernido Irradiación gama Isoquinoleína Molécula pequeña Método acoplado Pirimidina derivado Radioquímica Reacción radicalar Espectrometría masa Síntesis química Tacrina Prueba actividad Acetylcholinesterase Anticolinesterasa agente Carboxylic ester hydrolases Enzima Esterases Hydrolases Inhibidor enzima
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02W Miscellaneous

Discipline
General pharmacology
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
18099485

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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