Interleukin 6, a nuclear factor-κB target, predicts resistance to docetaxel in hormone-independent prostate cancer and nuclear factor-κB inhibition by PS-1145 enhances docetaxel antitumor activity
- Author
- DOMINGO-DOMENECH, Josep1 ; OLIVA, Cristina2 ; ROLFE, Mark4 ; ROSS, Jeffrey S5 ; GASCON, Pere1 ; ALBANELL, Joan1 2 ; MELLADO, Begona1 ; ROVIRA, Ana1 2 ; CODONY-SERVAT, Jordi1 ; BOSCH, Marta1 ; FILELLA, Xavier3 ; MONTAGUT, Clara1 ; TAPIA, Marian1 ; CAMPAS, Clara2 ; DANG, Lenny4
[1] Department of Medical Oncology and Laboratory of Experimental Oncology, Institut Clinic Malalties Hemato-Oncologiques, University of Barcelona, Barcelona, Spain
[2] Medical Oncology Department and Experimental Therapeutics Research Unit, Hospital del Mar, Instituto Municipal de Investigación Médica, Instituto Municipal de Asistencia Sanitaria, Barcelona, Spain
[3] Department of Biochemistry, Hospital Clinic and Institut d'lnvestigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
[4] Millennium Pharmaceuticals, Inc, Cambridge, Massachusetts, United States
[5] Department of Pathology and Laboratory Medicine, Albany Medical College, Albany, New York, United States - Source
Clinical cancer research. 2006, Vol 12, Num 18, pp 5578-5586, 9 p ; ref : 25 ref
- ISSN
- 1078-0432
- Scientific domain
- Medical oncology; Pharmacology drugs
- Publisher
- American Association for Cancer Research, Philadelphia, PA
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Activité biologique Anticancéreux Cancer prostate Ciblage Cible Docétaxel Facteur prédictif Facteur transcription NFκB Hormonoindépendance Inhibiteur Interleukine 6 Résistance Antimitotique Appareil génital mâle pathologie Appareil urinaire pathologie Cytokine Prostate pathologie Taxane dérivé Tumeur maligne
- Keyword (en)
- Biological activity Antineoplastic agent Prostate cancer Targeting Target Docetaxel Predictive factor Transcription factor NFκB Hormonoindependence Inhibitor Interleukin 6 Resistance Antimitotic Male genital diseases Urinary system disease Cytokine Prostate disease Taxane derivatives Malignant tumor
- Keyword (es)
- Actividad biológica Anticanceroso Cáncer de la próstata Blancado Blanco Docetaxel Factor predictivo Factor transcripción NFκB Hormonoindependencia Inhibidor Interleuquina 6 Resistencia Antimitótico Aparato genital macho patología Aparato urinario patología Citoquina Prostata patología Taxane derivado Tumor maligno
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B14 Nephrology. Urinary tract diseases / 002B14D Tumors of the urinary system / 002B14D02 Urinary tract. Prostate gland
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B20 Gynecology. Andrology. Obstetrics / 002B20B Male genital diseases / 002B20B02 Tumors
- Discipline
- Gynecology. Andrology. Obstetrics Nephrology. Urinary tract diseases Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 18149339
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1158/1078-0432.CCR-05-2767 
https://dx.doi.org/10.1158/1078-0432.CCR-05-2767
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