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Reactions of artemisinin and arteether with acid : Implications for stability and mode of antimalarial action

Author
DREW, Michael G. B1 ; METCALFE, John1 ; DASCOMBE, Michael J2 ; ISMAIL, Fyaz M. D3
[1] Department of Chemistry, University of Reading, Reading RG6 6AD, United Kingdom
[2] Faculty of Life Sciences, The University of Manchester, Stopford Building 1.124, Oxford Road, Manchester M13 9PT, United Kingdom
[3] The Medicinal Chemistry Research Group, The School of Pharmacy and Chemistry, Liverpool John Moores University, Liverpool L3 3AF, United Kingdom
Source

Journal of medicinal chemistry (Print). 2006, Vol 49, Num 20, pp 6065-6073, 9 p ; ref : 46 ref

CODEN
JMCMAR
ISSN
0022-2623
Scientific domain
Pharmacology drugs
Publisher
American Chemical Society, Washington, DC
Publication country
United States
Document type
Article
Language
English
Keyword (fr)
Acide Lewis Activité biologique Antipaludique Antiparasitaire Antiprotozoaire Artémisinine Artémotil Endoperoxyde Etude théorique Forme protonée Hydrolyse Lactone Mécanisme action Méthode fonctionnelle densité Sesquiterpène Stabilité Terpénoïde 3,12-Epoxypyrano[4,3-j]-1,2-benzodioxépine dérivé
Keyword (en)
Lewis acid Biological activity Antimalarial Parasiticide Antiprotozoal agent Artemisinin Artemotil Endoperoxide Theoretical study Protonated form Hydrolysis Lactone Mechanism of action Density functional method Sesquiterpenes Stability Terpenoid
Keyword (es)
Acido Lewis Actividad biológica Antipalúdico Antiparasitario Antiprotozoario Artemisinina Artemotilo Endoperóxido Estudio teórico Forma protonada Hidrólisis Lactona Mecanismo acción Sesquiterpeno Estabilidad Terpenoide
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S06 Antiparasitic agents

Discipline
Pharmacological treatments
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
18154128

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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