Regiospecific and highly stereoselective coupling of 6-(substituted-imidazol-1-yl)purines with 2-deoxy-3,5-di-O-(p-toluoyl)-α-D-erythro-pentofuranosyl chloride. Sodium-salt glycosylation in binary solvent mixtures : Improved synthesis of cladribine
- Author
- MINGHONG ZHONG1 ; NOWAK, Ireneusz1 ; ROBINS, Morris J1
[1] Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah 84602-5700, United States - Source
Journal of organic chemistry. 2006, Vol 71, Num 20, pp 7773-7779, 7 p ; ref : 37 ref
- CODEN
- JOCEAH
- ISSN
- 0022-3263
- Scientific domain
- Biochemistry, molecular biology, biophysics; Organic chemistry
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Acétonitrile Ammoniac Ammoniolyse Anomère Anomérisation Anticancéreux Base purique Benzylation Cation organique Chlore composé organique Composé lipophile Composé soluble Configuration Désoxyadénosine Glycosylation Hétérocycle azote Imidazole dérivé Médicament Mélange binaire Méthane(dichloro) Méthanol Protection Purine dérivé Régiospécificité Sodium composé Solubilité Solvant apolaire Solvant organique Solvant polaire Solvatation Stéréoisomère D-érythro Stéréosélectivité Synthèse chimique Sélectivité Imidazolium composé
- Keyword (en)
- Acetonitrile Ammonia Ammonolysis Anomer Anomerization Antineoplastic agent Purine base Benzylation Organic cation Organic chlorine compounds Lipophilic compound Soluble compound Configuration Deoxyadenosine Glycosylation Nitrogen heterocycle Imidazole derivatives Drug Binary mixture Dichloromethane Methanol Protection Purine derivatives Regiospecificity Sodium compound Solubility Apolar solvent Organic solvent Polar solvent Solvation D-erythro stereoisomer Stereoselectivity Chemical synthesis Selectivity
- Keyword (es)
- Acetonitrilo Amoníaco Amoniolisis Anómero Anomerización Anticanceroso Base púrica Bencilación Catión orgánico Compuesto lipófilo Compuesto soluble Configuración Desoxiadenosina Glicosilación Heterociclo nitrógeno Imidazol derivado Medicamento Mezcla binaria Metano(dicloro) Metanol Protección Purina derivado Regiospecificidad Sodio compuesto Solubilidad Disolvente apolar Solvente orgánico Disolvente polar Solvatación Estereoisómero D-eritro Estereoselectividad Síntesis química Selectividad
- Classification
- Pascal
- 001 Exact sciences and technology / 001C Chemistry / 001C03 Organic chemistry / 001C03C Preparations and properties / 001C03C06 Heterocyclic compounds / 001C03C06C Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings
- Discipline
- Organic chemistry
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 18154482
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jo061282+ 
https://dx.doi.org/10.1021/jo061282+
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