Single- chain antibodies to the EWS NH2 terminus structurally discriminate between intact and chimeric EWS in ewing's sarcoma and interfere with the transcriptional activity of EWS in vivo
- Author
- ARYEE, Dave N. T1 ; KREPPEL, Michael1 ; BACHMAIER, Radostina1 ; ÜREN, Aykut2 ; MUEHLBACHER, Karin1 ; WAGNER, Stefan3 ; BREITENEDER, Heimo3 ; BAN, Jozef1 ; TORETSKY, Jeffrey A2 ; KOVAR, Heinrich1
[1] Children's Cancer Research Institute, Medical University of Vienna, Vienna, Austria
[2] Departments of Oncology and Pediatrics, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia, United States
[3] Institute of Pathophysiology, Medical University of Vienna, Vienna, Austria - Source
Cancer research (Baltimore). 2006, Vol 66, Num 20, pp 9862-9869, 8 p ; ref : 26 ref
- CODEN
- CNREA8
- ISSN
- 0008-5472
- Scientific domain
- Medical oncology; Pharmacology drugs
- Publisher
- American Association for Cancer Research, Philadelphia, PA
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Activité biologique Anticorps simple chaîne Chimérisme Gène onc cellulaire In vivo Protooncogène Sarcome Ewing Transcription Gène EWS Système ostéoarticulaire pathologie Tumeur maligne
- Keyword (en)
- Biological activity Single chain antibody Chimerism C-Onc gene In vivo Protooncogene Ewing sarcoma Transcription Diseases of the osteoarticular system Malignant tumor
- Keyword (es)
- Actividad biológica Anticuerpo simple cadena Quimerismo Gen onc celular In vivo Protooncogen Sarcoma Ewing Transcripción Sistema osteoarticular patología Tumor maligno
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B15 Diseases of the osteoarticular system / 002B15C Tumors of striated muscle and skeleton
- Discipline
- Osteoarticular pathology Pharmacological treatments Tumours
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 18209295
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1158/0008-5472.CAN-05-4042 
https://dx.doi.org/10.1158/0008-5472.CAN-05-4042
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