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Increased frequencies of CD8+ T lymphocytes recognizing wild-type p53-derived epitopes in peripheral blood correlate with presence of epitope loss tumor variants in patients with hepatocellular carcinoma

Author
CICINNATI, Vito R1 2 ; XIA ZHANG1 ; SCHMID, Kurt W4 ; GROSSE-WILDE, Hans3 ; BROELSCH, Christoph E2 ; DELEO, Albert B7 8 ; GERKEN, Guido1 ; BECKEBAUM, Susanne1 2 ; ZHENGYA YU2 ; FERENCIK, Stanislav3 ; SCHMITZ, Klaus J4 ; DWORACKI, Grzegorz5 6 ; KACZMAREK, Elzbieta5 ; OLDHAFER, Karl2 ; FRILLING, Andrea2 ; BABA, Hideo A4
[1] Department of Gastroenterology and Hepatology, University Hospital Essen, University of Duisburg-Essen, Germany
[2] Department of General, Visceral and Transplantation Surgery, University Hospital Essen, University of Duisburg-Essen, Germany
[3] Institute of Immunology, University Hospital Essen, University of Duishurg-Essen, Germany
[4] Institute of Pathology, University Hospital Essen, University of Duisburg-Essen, Germany
[5] Institute of Pathology, University of Medical Sciences, Poznan, Poland
[6] Department of Clinical Immunology, University of Medical Sciences, Poznan, Poland
[7] Division of Basic Research, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA, United States
[8] Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States
Source

International journal of cancer. = Journal international du cancer. 2006, Vol 119, Num 12, pp 2851-2860, 10 p ; ref : 58 ref

CODEN
IJCNAW
ISSN
0020-7136
Scientific domain
Medical oncology
Publisher
Wiley-Liss, New York, NY
Publication country
United States
Document type
Article
Language
English
Author keyword
cytotoxic T lymphocyte hepatocellular carcinoma immunotherapy p53 tumor escape
Keyword (fr)
Cancer foie Cancérologie Carcinome hépatocellulaire Cellule suppressive Déterminant antigénique Gène TP53 Gène suppresseur tumeur Homme Immunité cellulaire Immunosurveillance Lymphocyte T cytotoxique Réponse immune Sang Antigène CD8 Gène p53 Type sauvage Appareil digestif pathologie Foie pathologie Génétique Tumeur maligne
Keyword (en)
Liver cancer Cancerology Hepatocellular carcinoma Suppressive cell Antigenic determinant TP53 Gene Tumor suppressor gene Human Cellular immunity Immunological surveillance Cytotoxic T lymphocyte Immune response Blood Wild type Digestive diseases Hepatic disease Genetics Malignant tumor
Keyword (es)
Cáncer del hígado Cancerología Carcinoma hepatocelular Célula supresora Determinante antigénico Gen TP53 Gen supresor tumor Hombre Inmunidad celular Inmunovigilancia Linfocito T citotóxico Respuesta inmune Sangre Tipo salvaje Aparato digestivo patología Hígado patología Genética Tumor maligno
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B04 Tumors

Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B13 Gastroenterology. Liver. Pancreas. Abdomen / 002B13C Liver. Biliary tract. Portal circulation. Exocrine pancreas / 002B13C01 Tumors

Discipline
Gastroenterology. Liver. Pancreas. Abdomen Tumours
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
18305793

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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