Downregulation of PS1 expression in neurons decreases beta-amyloid production : a biochemical link between the two major familial Alzheimer's disease genes
- Author
- SAFTIG, P1 ; DE STROOPER, B2
[1] Zentrum Biochemie und Molekulare Zellbiologie, Abteilung Biochemie II, Universität Göttingen, Germany
[2] Center for Human Genetics, EGG Flemish Institute for Biotechnology (VIB4), KU Leuven, Belgium - Source
Molecular psychiatry. 1998, Vol 3, Num 4, pp 287-289 ; ref : 15 ref
- ISSN
- 1359-4184
- Scientific domain
- Biochemistry, molecular biology, biophysics; Psychology, psychopathology, psychiatry
- Publisher
- Nature Publishing Group, Basingstoke
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Animal transgénique Démence Alzheimer Encéphale Expression génique Génétique Neurone Pathogénie Protéine amyloïde β Protéine précurseur amyloïde Préséniline Souris Système nerveux central Souris Knockout Encéphale pathologie Maladie dégénérative Mammalia Rodentia Système nerveux central pathologie Système nerveux pathologie Vertebrata
- Keyword (en)
- Transgenic animal Alzheimer disease Brain (vertebrata) Gene expression Genetics Neuron Pathogenesis β Amyloid protein Amyloid precursor protein Presenilin Mouse Central nervous system Cerebral disorder Degenerative disease Mammalia Rodentia Central nervous system disease Nervous system diseases Vertebrata
- Keyword (es)
- Animal transgénico Demencia Alzheimer Encéfalo Expresión genética Genética Neurona Patogenia Proteína amiloide β Proteína precursor amiloide Presenilina Ratón Sistema nervioso central Encéfalo patología Enfermedad degenerativa Mammalia Rodentia Sistema nervosio central patología Sistema nervioso patología Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B17 Neurology / 002B17G Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
- Discipline
- Neurology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 1835556
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/sj.mp.4000408 
https://dx.doi.org/10.1038/sj.mp.4000408
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