Rational design of a nonpeptide general chemical scaffold for reversible inhibition of PDZ domain interactions
- Author
- FUJII, Naoaki1 ; HARESCO, Jose J2 ; NOVAK, Kathleen A. P1 ; GAGE, Robert M3 ; PEDEMONTE, Nicoletta4 ; STOKOE, David5 ; KUNTZ, Irwin D1 2 ; KIPLIN GUY, R1 3
[1] Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143, United States
[2] Laboratory for Molecular Dynamics and Design, University of California, San Francisco, CA 94143, United States
[3] Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143, United States
[4] Laboratory of Molecular Genetics, Giannina Gaslini Institute, Genova 16148, Italy
[5] Comprehensive Cancer Center, University of California, San Francisco, CA 94143, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2007, Vol 17, Num 2, pp 549-552, 4 p ; ref : 12 ref
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Drug design Interaction NHERF PDZ domain Protein-protein
- Keyword (fr)
- Alcool Composé non peptide Domaine moléculaire Embryon Fixation ligand Gène PTEN Gène suppresseur tumeur Homme In vitro Indole dérivé Inhibition Interaction moléculaire Lignée cellulaire Modèle moléculaire Modélisation Molécule petite Prédiction Rein Relation structure activité Site fixation Synthèse chimique Domaine PDZ Facteur NHERF Indole-6-carboxylique acide(2-[1-hydroxypentyl]-5-méthyl-1-phénéthyl) Lignée HEK293 Protéine MAGUK
- Keyword (en)
- Alcohol Non peptide compound Molecular domain Embryo Ligand binding PTEN Gene Tumor suppressor gene Human In vitro Indole derivatives Inhibition Molecular interaction Cell line Molecular model Modeling Small molecule Prediction Kidney Structure activity relation Binding site Chemical synthesis Na/H exchanger regulatory factor Membrane associated guanylate kinase
- Keyword (es)
- Alcohol Compuesto no péptido Dominio molecular Embrión Fijación ligando Gen PTEN Gen supresor tumor Hombre In vitro Indol derivado Inhibición Interacción molecular Línea celular Modelo molecular Modelización Molécula pequeña Predicción Riñón Relación estructura actividad Sitio fijación Síntesis química
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02W Miscellaneous
- Discipline
- General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 18461282
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2006.10.006 
https://dx.doi.org/10.1016/j.bmcl.2006.10.006
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