Lyn is an important component of the signal transduction pathway specific to FLT3/ITD and can be a therapeutic target in the treatment of AML with FLT3/ITD
- Author
- OKAMOTO, M1 ; HAYAKAWA, F1 ; MIYATA, Y1 ; WATAMOTO, K1 ; EMI, N1 ; ABE, A1 ; KIYOI, H2 ; TOWATARI, M1 ; NAOE, T1
[1] Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
[2] Department of Infectious Diseases, Graduate School of Medicine, Nagoya University, Nagoya, Japan - Source
Leukemia. 2007, Vol 21, Num 3, pp 403-410, 8 p ; ref : 32 ref
- CODEN
- LEUKED
- ISSN
- 0887-6924
- Scientific domain
- Medical oncology; Hematology
- Publisher
- Nature Publishing, London
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- FLT3 Lyn STAT5 Src family kinase kinase inhibitor molecular targeting therapy
- Keyword (fr)
- Ciblage Facteur transcription STAT5 Gène onc cellulaire Hématologie Inhibiteur Kinase Protein-tyrosine kinase Protooncogène Traitement Transduction signal Leucémie aiguë myéloblastique Lyn protein tyrosine kinase Récepteur tyrosine kinase FLT3 Src protein kinase Thérapeutique ciblée Enzyme Hémopathie maligne Transferases
- Keyword (en)
- Targeting Transcription factor STAT5 C-Onc gene Hematology Inhibitor Kinase Protein-tyrosine kinase Protooncogene Treatment Signal transduction Acute myelocytic leukemia Lyn protein tyrosine kinase Fms-like tyrosine kinase 3 Targeted therapy Enzyme Malignant hemopathy Transferases
- Keyword (es)
- Blancado Factor transcripción STAT5 Gen onc celular Hematología Inhibidor Kinase Protein-tyrosine kinase Protooncogen Tratamiento Transducción señal Leucemia mieloblástica Lyn protein tyrosine kinase Terapéutica blanca Enzima Hemopatía maligna Transferases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B19 Hematologic and hematopoietic diseases / 002B19B Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
- Discipline
- Blood diseases
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 18554360
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/sj.leu.2404547 
https://dx.doi.org/10.1038/sj.leu.2404547
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