Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution
- Author
- HELGASON, Agnar1 ; PALSSON, Snaebjörn1 2 ; BENEDIKTSSON, Rafn4 5 ; HINNEY, Anke6 ; HANSEN, Torben7 ; ANDERSEN, Gitte7 ; BORCH-JOHNSEN, Knut7 8 ; JORGENSEN, Torben9 ; SCHÄFER, Helmut10 ; FARUQUE, Mezbah3 ; DOUMATEY, Ayo3 ; JIE ZHOU3 ; THORLEIFSSON, Gudmar1 ; WILENSKY, Robert L11 ; REILLY, Muredach P11 ; RADER, Daniel J11 ; BAGGER, Yu12 ; CHRISTIANSEN, Claus12 ; SIGURDSSON, Gunnar4 5 ; HEBEBRAND, Johannes6 ; PEDERSEN, Oluf7 8 ; THORSTEINSDOTTIR, Unnur1 ; GULCHER, Jeffrey R1 ; GRANT, Struan F. A1 ; KONG, Augustine1 ; ROTIMI, Charles3 ; STEFANSSON, Kari1 ; EMILSSON, Valur1 ; GUNNARSDOTTIR, Steinunn1 ; ADEYEMO, Adebowale3 ; YUANXIU CHEN3 ; GUANJIE CHEN3 ; REYNISDOTTIR, Inga1
[1] deCODE genetics, 101 Reykjavik, Iceland
[2] University of Iceland, 101 Reykjavik, Iceland
[3] National Human Genome Center, Department of Community and Family Medicine, Howard University, Washington DC 20060, United States
[4] Icelandic Heart Association, 201 Kopavogur, Iceland
[5] National University Hospital, 101 Reykjavik, Iceland
[6] Department of Child and Adolescent Psychiatry, Rheinische Kliniken Essen, University of Duisburg-Essen, 45147 Essen, Germany
[7] Steno Diabetes Center, 2820 Gentofte, Denmark
[8] University of Aarhus, 8000 Aarhus, Denmark
[9] Research Centre for Prevention and Health, University Hospital Glostrup, 2600 Glostrup, Denmark
[10] Institute of Medical Biometry and Epidemiology, Philipps-University of Marburg, 35037 Marburg, Germany
[11] University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, United States
[12] Center for Clinical and Basic Research A/S, 2750 Ballerup, Denmark - Source
Nature genetics. 2007, Vol 39, Num 2, pp 218-225, 8 p ; ref : 30 ref
- Publisher
- Nature Publishing Group, London
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Diabète type 2 Evolution moléculaire Gène Variant Endocrinopathie Métabolisme pathologie
- Keyword (en)
- Type 2 diabetes Molecular evolution Gene Variant Endocrinopathy Metabolic diseases
- Keyword (es)
- Diabetes de tipo 2 Evolución molecular Gen Variante Endocrinopatía Metabolismo patología
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A07 Genetics of eukaryotes. Biological and molecular evolution
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B21 Endocrinopathies / 002B21E Endocrine pancreas. Apud cells (diseases) / 002B21E01 Diabetes. Impaired glucose tolerance / 002B21E01A Etiopathogenesis. Screening. Investigations. Target tissue resistance
- Discipline
- Endocrinopathies Eukaryotes genetics. Biological and molecular evolution
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 18572594
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/ng1960 
https://dx.doi.org/10.1038/ng1960
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