Recombinant human antithrombin expressed in chinese hamster ovary cells shows in vivo efficacy on rat DIC model similarly to plasma-derived antithrombin regardless of different N-glycosylation
- Author
- HIROSE, Masaaki1 ; TSUKADA, Minoru2 ; HIRAYAMA, Fumihiro2 ; KUBO, Yoshiji2 ; KAJII, Masahiko2 ; MOCHIZUKI, Shinobu1 ; HAMATO, Nobuaki1 ; OHI, Hideyuki1
[1] Protein Research Laboratory, Pharmaceutical Research Division, Mitsubishi Pharma Corporation, 2-25-1, Shodai-Ohtani, Hirakata, Osaka, 573-1153, Japan
[2] Hirakata Laboratory, Research and Development Division, Benesis Corporation, Osaka, Japan - Source
Thrombosis research. 2007, Vol 119, Num 5, pp 631-641, 11 p ; ref : 49 ref
- CODEN
- THBRAA
- ISSN
- 0049-3848
- Scientific domain
- Cardiology, blood circulation, phlebology; Hematology
- Publisher
- Elsevier Science, New York, NY
- Publication country
- United States
- Document type
- Article
- Language
- English
- Author keyword
- Antithrombin DIC N-Glycosylation β-lsoform
- Keyword (fr)
- Alanine transaminase Animal Antithrombine Appareil circulatoire pathologie Aspartate transaminase Chinois Coagulation intravasculaire disséminée Coagulopathie Demi vie Fibrinogène Glycosylation Hamster Homme Hémostatique Héparine cofacteur Lipopolyoside Ovaire Pharmacocinétique Rat Substitut Thrombin Thrombocyte Thromboplastine Traitement Appareil génital femelle Enzyme Hydrolases Hémopathie Mammalia Peptidases Rodentia Serine endopeptidases Transaminases Transferases Vertebrata
- Keyword (en)
- Alanine transaminase Animal Antithrombin Cardiovascular disease Aspartate transaminase Chinese Disseminated intravascular coagulopathy Coagulopathy Half life Fibrinogen Glycosylation Hamster Human Hemostatic Heparin cofactor Lipopolysaccharide Ovary Pharmacokinetics Rat Substitute Thrombin Platelet Thromboplastin Treatment Female genital system Enzyme Hydrolases Hemopathy Mammalia Peptidases Rodentia Serine endopeptidases Transaminases Transferases Vertebrata
- Keyword (es)
- Alanine transaminase Animal Antitrombina Aparato circulatorio patología Aspartate transaminase Chino Coagulación intravascular diseminada Coagulopatía Media vida Fibrinógeno Glicosilación Hamster Hombre Hemostático Heparina cofactor Lipopoliósido Ovario Farmacocinética Rata Substituto Thrombin Trombocito Tromboplastina Tratamiento Aparato genital hembra Enzima Hydrolases Hemopatía Mammalia Peptidases Rodentia Serine endopeptidases Transaminases Transferases Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A22 Vertebrates: cardiovascular system / 002A22D Blood vessels and receptors
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02F Cardiovascular system / 002B02F07 Vascular wall
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B12 Cardiology. Vascular system / 002B12B Blood and lymphatic vessels / 002B12B03 Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
- Discipline
- Cardiology. Circulatory system Pharmacological treatments Vertebrates : cardiovascular system
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 18611421
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.thromres.2006.05.010 
https://dx.doi.org/10.1016/j.thromres.2006.05.010
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