Down-regulation of the pharmacokinetic-pharmacodynamic response to interleukin-12 during long-term administration to patients with renal cell carcinoma and evaluation of the mechanism of this adaptive response in mice
- Author
- RAKHIT, A; YEON, M. M; MAGRAM, J; GATELY, M. K; FERRANTE, J; FETTNER, S; NADEAU, R; MOTZER, R; BUKOWSKI, R; CARVAJAL, D. M; WILKINSON, V. L; PRESKY, D. H
Cleveland Clinic Foundation, Cleveland, United States
Department of Clinical Pharmacology, Department of Inflammation/Autoimmune Diseases and Department of Drug Metabolism-Pharmacokinetics, Hoffmann-La Roche Inc, Nutley, United States
Memorial Sloan-Kettering Cancer Center, New York, United States - Source
Clinical pharmacology and therapeutics. 1999, Vol 65, Num 6, pp 615-629 ; ref : 39 ref
- CODEN
- CLPTAT
- ISSN
- 0009-9236
- Scientific domain
- Pharmacology drugs
- Publisher
- Nature Publishing, New York, NY
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Animal Carcinome Cytokine Dose répétée Dose unique Essai clinique phase I Homme Hypernéphrome Immunothérapie Interféron gamma Interleukine 12 Long terme Pharmacocinétique Plasma sanguin Relation pharmacocinétique pharmacodynamie Réponse immune Sang Souris Toxicité Traitement Voie souscutanée Appareil urinaire pathologie Mammalia Rein pathologie Rodentia Tumeur maligne Vertebrata
- Keyword (en)
- Animal Carcinoma Cytokine Multiple dose Single dose Phase I trial Human Grawitz tumor Immunotherapy Gamma interferon Interleukin 12 Long term Pharmacokinetics Blood plasma Pharmacokinetic pharmacodynamic relationship Immune response Blood Mouse Toxicity Treatment Subcutaneous administration Urinary system disease Mammalia Kidney disease Rodentia Malignant tumor Vertebrata
- Keyword (es)
- Animal Carcinoma Citoquina Dosis múltiple Dosis única Ensayo clínico fase I Hombre Hipernefroma Inmunoterapia Interferón gamma Interleuquina 12 Largo plazo Farmacocinética Plasma sanguíneo Relación farmacocinética farmacodinamia Respuesta inmune Sangre Ratón Toxicidad Tratamiento Vía subcutánea Aparato urinario patología Mammalia Riñón patología Rodentia Tumor maligno Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R03 Immunotherapy
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 1865754
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/S0009-9236(99)90083-8 
https://dx.doi.org/10.1016/S0009-9236(99)90083-8
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