Selective inhibition of carboxylesterases by isatins, indole-2,3-diones
- Author
- HYATT, Janice L1 ; MOAK, Ten2 ; HATFIELD, M. Jason1 ; TSURKAN, Lyudmila1 ; EDWARDS, Carol C1 ; WIERDL, Monika1 ; DANKS, Mary K1 ; WADKINS, Randy M2 ; POTTER, Philip M1
[1] Department of Molecular Pharmacology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, United States
[2] Department of Chemistry and Biochemistry, University of Mississippi, University, Mississippi 38677, United States - Source
Journal of medicinal chemistry (Print). 2007, Vol 50, Num 8, pp 1876-1885, 10 p ; ref : 46 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Carboxylesterase Complexe enzyme inhibiteur Composé aromatique Composé bicyclique Homme Hétérocycle azote Indole dérivé Inhibiteur enzyme Isatine Lipophilie Modèle 3 dimensions Modèle moléculaire Modélisation Propriété physicochimique Prédiction Relation propriété physicochimique activité Relation structure activité Relation structure propriété Site actif Sélectivité Indole-2,3-dione dérivé Indole-2,3-dione Carboxylic ester hydrolases Enzyme Esterases Hydrolases
- Keyword (en)
- Carboxylesterase Inhibitor enzyme complex Aromatic compound Bicyclic compound Human Nitrogen heterocycle Indole derivatives Enzyme inhibitor Lipophilicity Three dimensional model Molecular model Modeling Physicochemical properties Prediction Physicochemical properties activity relationship Structure activity relation Property structure relationship Active site Selectivity Carboxylic ester hydrolases Enzyme Esterases Hydrolases
- Keyword (es)
- Carboxylesterase Complejo enzima inhibidor Compuesto aromático Compuesto bicíclico Hombre Heterociclo nitrógeno Indol derivado Inhibidor enzima Lipofilia Modelo 3 dimensiones Modelo molecular Modelización Propiedad fisicoquímica Predicción Relación propiedad fisicoquímica actividad Relación estructura actividad Relación estructura propiedad Lugar activo Selectividad Carboxylic ester hydrolases Enzima Esterases Hydrolases
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A02 Analytical, structural and metabolic biochemistry / 002A02E Enzymes and enzyme inhibitors / 002A02E04 Hydrolases
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02W Miscellaneous
- Discipline
- Analytical, structural and metabolic biochemistry General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 18714630
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm061471k 
https://dx.doi.org/10.1021/jm061471k
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