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Radioiodination of new EGFR inhibitors as potential SPECT agents for molecular imaging of breast cancer

Author
FERNANDES, Célia1 ; OLIVEIRA, Cristina1 ; GANO, Lurdes1 ; BOURKOULA, Athanasia2 ; PIRMETTIS, Ioannis2 ; SANTOS, Isabel1
[1] Departamento de Quimica, ITN, Estrada Nacional 10, 2686-953, Sacavém, Portugal
[2] Institute of Radioisotopes-Radiodiagnostic Products, NCSR Demokritos, Athens, Greece
Source

Bioorganic & medicinal chemistry. 2007, Vol 15, Num 12, pp 3974-3980, 7 p

ISSN
0968-0896
Scientific domain
Biochemistry, molecular biology, biophysics; Pharmacology drugs
Publisher
Elsevier Science, Oxford
Publication country
United Kingdom
Document type
Article
Language
English
Author keyword
Cancer EGFR Quinazoline SPECT Tyrosine kinase inhibitors
Keyword (fr)
Activité biologique Agent scintigraphique Animal Autophosphorylation Brome composé organique Carcinome épidermoïde Cellule tumorale Chlore composé organique Chromatographie HPLC Chromatographie phase inverse Fluor composé organique Formation image Glande mammaire Homme In vitro In vivo Inhibiteur enzyme Inhibition Iodation Iode 125 Iode Isotope Ligand Lignée cellulaire Marquage radioisotopique Multiplication cellulaire Protein-tyrosine kinase Purification Quinazoline dérivé Récepteur facteur croissance épiderme Souris Stabilité radiochimique Synthèse chimique Tomographie émission simple photon Transduction signal Transhalogénation Tumeur maligne Lignée A431 Propionamide dérivé Quinazoline(4-[3-chloro-4-fluoroanilino]-6-[3-iodopropionamido]) Radioiodation Radioligand Enzyme Mammalia Rodentia Transferases Vertebrata
Keyword (en)
Biological activity Scintigraphic agent Animal Autophosphorylation Organic bromine compounds Squamous cell carcinoma Tumor cell Organic chlorine compounds HPLC chromatography Reversed phase chromatography Organic fluorine compounds Imaging Mammary gland Human In vitro In vivo Enzyme inhibitor Inhibition Iodination Iodine 125 Iodine Isotopes Ligand Cell line Radiolabelling Cell proliferation Protein-tyrosine kinase Purification Quinazoline derivatives Epidermal growth factor receptor Mouse Radiochemical stability Chemical synthesis Single photon emission computed tomography Signal transduction Transhalogenation Malignant tumor Enzyme Mammalia Rodentia Transferases Vertebrata
Keyword (es)
Actividad biológica Agente centelleográfico Animal Autofosforilación Carcinoma epidermoide Célula tumoral Cromatografía HPLC Cromatografía fase inversa Formación imagen Glándula mamaria Hombre In vitro In vivo Inhibidor enzima Inhibición Iodación Iodo Isótopo Ligando Línea celular Marcación radioisotópica Multiplicación celular Protein-tyrosine kinase Purificación Receptor factor crecimiento epidermi Ratón Estabilidad radioquímica Síntesis química Transducción señal Transhalogenación Tumor maligno Enzima Mammalia Rodentia Transferases Vertebrata
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02T Contrast media. Radiopharmaceuticals

Discipline
Pharmacological treatments
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
18744906

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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