Rapid evolution of 6-phenylpurine inhibitors of protein kinase b through structure-based design
- Author
- DONALD, Alastair1 ; MCHARDY, Tatiana1 ; ROWLANDS, Martin G1 ; HUNTER, Lisa-Jane K1 ; DAVIES, Thomas G2 ; BERDINI, Valerio2 ; BOYLE, Robert G2 ; AHEME, G. Wynne1 ; GARRETT, Michelle D1 ; COLLINS, Ian1
[1] Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, United Kingdom
[2] Astex Therapeutics Ltd., 436 Cambridge Science Park, Milton Road, Cambridge, CB4 0QA, United Kingdom - Source
Journal of medicinal chemistry (Print). 2007, Vol 50, Num 10, pp 2289-2292, 4 p ; ref : 27 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Akt protein kinase Cellule tumorale Complexe enzyme inhibiteur Cytotoxicité Diffraction RX Homme In vitro Inhibiteur Lignée cellulaire Méthode immunoblotting Propriété physicochimique Protein kinase Purine dérivé Relation structure activité Relation structure propriété Structure cristalline Structure moléculaire Synthèse chimique Transduction signal Purine(6-[4-(4-[4-chlorophényl]-4-pipéridyl)phényl]) Enzyme Transferases
- Keyword (en)
- Akt protein kinase Tumor cell Inhibitor enzyme complex Cytotoxicity X ray diffraction Human In vitro Inhibitor Cell line Immunoblotting assay Physicochemical properties Protein kinase Purine derivatives Structure activity relation Property structure relationship Crystalline structure Molecular structure Chemical synthesis Signal transduction Enzyme Transferases
- Keyword (es)
- Akt protein kinase Célula tumoral Complejo enzima inhibidor Citotoxicidad Difracción RX Hombre In vitro Inhibidor Línea celular Western blotting Propiedad fisicoquímica Protein kinase Purina derivado Relación estructura actividad Relación estructura propiedad Estructura cristalina Estructura molecular Síntesis química Transducción señal Enzima Transferases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 18767476
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm0700924 
https://dx.doi.org/10.1021/jm0700924
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