Conformationally restricted homotryptamines 3. Indole tetrahydropyridines and cyclohexenylamines as selective serotonin reuptake inhibitors
- Author
- DESKUS, Jeffrey A1 ; EPPERSON, James R1 ; MOLSKI, Thaddeus F1 ; KRAUSE, Rudolph G1 ; TABER, Matthew T1 ; LODGE, Nicholas J1 ; MATTSON, Ronald J1 ; SLOAN, Charles P1 ; CIPOLLINA, Joseph A1 ; DEXTRAZE, Pierre1 ; QIAN-CUTRONE, Jingfang1 ; QI GAO1 ; BAOQING MA1 ; BENO, Brett R1 ; MATTSON, Gail K1
[1] Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492-7660, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2007, Vol 17, Num 11, pp 3099-3104, 6 p ; ref : 16 ref
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Homotryptamine SSRI Serotonin transporter
- Keyword (fr)
- Activité biologique Animal Enantiomère Encombrement stérique Fixation biologique Fluoxétine Homme In vitro Indole dérivé Inhibiteur recapture Inhibiteur sélectif recapture sérotonine Neurotransmetteur Nitrile Protéine transport Pyridine dérivé Rat Rigidité moléculaire Synthèse chimique Sérotonine Transport membranaire Cyclohexène dérivé Indole-5-carbonitrile(3-[4-(diméthylamino)cyclohex-1-ényl]) Transporteur sérotonine Mammalia Rodentia Vertebrata
- Keyword (en)
- Biological activity Animal Enantiomer Steric hindrance Biological fixation Fluoxetine Human In vitro Indole derivatives Reuptake inhibitor Selective serotonin reuptake inhibitor Neurotransmitter Nitrile Carrier protein Pyridine derivatives Rat Molecular rigidity Chemical synthesis Serotonin Membrane transport Mammalia Rodentia Vertebrata
- Keyword (es)
- Actividad biológica Animal Enantiómero Embarazo estérico Fijación biológica Fluoxetina Hombre In vitro Indol derivado Inhibidor recaptura Inhibidor selectivo recaptura serotonin Neurotransmisor Nitrilo Proteína transportador Piridina derivado Rata Rigidez molecular Síntesis química Serotonina Transporte membranal Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09C Serotoninergic system
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 18768680
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2007.03.040 
https://dx.doi.org/10.1016/j.bmcl.2007.03.040
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