2 -Hydroxy -N -arylbenzenesulfonamides as ATP-citrate lyase inhibitors
- Author
- LI, James J1 ; HAIXIA WANG1 ; CHU, Ching-Hsuen1 ; FLYNN, Neil1 ; DONG CHENG1 ; RULIN ZHAO1 ; BANGCHI CHEN1 ; SCHNUR, Dora1 ; OBERMEIER, Mary T1 ; SASSEVILLE, Vito1 ; PADMANABHA, Ramesh2 ; PIKE, Kristen2 ; TINO, Joseph A1 ; HARRITY, Thomas1 ; ROBL, Jeffrey A1 ; HERPIN, Timothy F1 ; LAWRENCE, R. Michael1 ; BILLER, Scott1 ; JAMIL, Haris1 ; PONTICIELLO, Randy1 ; LUPING CHEN1
[1] Bristol-Myers Squibb Pharmaceutical Research Institute, PO Box 5400, Princeton, NJ 08543-5400, United States
[2] Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2007, Vol 17, Num 11, pp 3208-3211, 4 p ; ref : 22 ref
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- ATP-citrate lyase (ACL) inhibitors Glycemic profiles and weight loss Lipid
- Keyword (fr)
- ATP citrate (pro-S)-lyase Animal Chlore composé organique Cholestérol Chronique Glucose Hypoglycémiant Hypolipémiant In vitro In vivo Inhibiteur enzyme Inhibition Perte poids Phénols Plasma sanguin Relation structure activité Souris Sulfonamide Synthèse chimique Triglycéride Voie orale Benzènesulfonamide(3,5-dichloro-2-hydroxy-N-[2,4,6-triphénylphényl]) Carbon-carbon lyases Enzyme Lyases Mammalia Oxo-acid-lyases Rodentia Vertebrata
- Keyword (en)
- ATP citrate (pro-S)-lyase Animal Organic chlorine compounds Cholesterol Chronic Glucose Hypoglycemic agent Antilipemic agent In vitro In vivo Enzyme inhibitor Inhibition Weight loss Phenols Blood plasma Structure activity relation Mouse Sulfonamide Chemical synthesis Triglyceride Oral administration Carbon-carbon lyases Enzyme Lyases Mammalia Oxo-acid-lyases Rodentia Vertebrata
- Keyword (es)
- ATP citrate (pro-S)-lyase Animal Colesterol Crónico Glucosa Hipoglicemiante Hipolipemiante In vitro In vivo Inhibidor enzima Inhibición Adelgazamiento Fenoles Plasma sanguíneo Relación estructura actividad Ratón Sulfonamida Síntesis química Triglicérido Vía oral Carbon-carbon lyases Enzima Lyases Mammalia Oxo-acid-lyases Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02N General and cellular metabolism. Vitamins
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 18768702
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2007.03.017 
https://dx.doi.org/10.1016/j.bmcl.2007.03.017
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