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Inhibition of p38α mitogen-activated protein kinase prevents the development of osteolytic bone disease, reduces tumor burden, and increases survival in murine models of multiple myeloma

Author
VANDERKERKEN, Karin1 ; MEDICHERLA, Satya2 ; CROUCHER, Peter I3 ; COULTON, Les3 ; DE RAEVE, Hendrik4 ; WILLEMS, Angelo1 ; LAWSON, Michelle3 ; VAN CAMP, Ben1 ; PROTTER, Andrew A2 ; HIGGINS, Linda S2 ; MENU, Eline1
[1] Department of Hematology and Immunology, Vrije Universiteit Brussel (VUB), Brussels, Belgium
[2] Scios, Inc, Fremont, California, United States
[3] Academic Unit of Bone Biology, University of Sheffield School of Medicine and Biomedical Science, Sheffield, United Kingdom
[4] Department of Pathology, University Hospital Antwerp, Antwerp, Belgium
Source

Cancer research (Baltimore). 2007, Vol 67, Num 10, pp 4572-4577, 6 p ; ref : 13 ref

CODEN
CNREA8
ISSN
0008-5472
Scientific domain
Medical oncology; Pharmacology drugs
Publisher
American Association for Cancer Research, Philadelphia, PA
Publication country
United States
Document type
Article
Language
English
Keyword (fr)
Inhibiteur enzyme Mitogen-activated protein kinase Modèle animal Myélome Ostéolyse Prévention Souris Survie Système ostéoarticulaire pathologie Tumeur osseuse Enzyme Hémopathie maligne Immunoglobulinopathie Immunopathologie Lymphoprolifératif syndrome Mammalia Rodentia Vertebrata
Keyword (en)
Enzyme inhibitor Mitogen-activated protein kinase Animal model Myeloma Osteolysis Prevention Mouse Survival Diseases of the osteoarticular system Bone tumor Enzyme Malignant hemopathy Immunoglobulinopathy Immunopathology Lymphoproliferative syndrome Mammalia Rodentia Vertebrata
Keyword (es)
Inhibidor enzima Mitogen-activated protein kinase Modelo animal Mieloma Osteólisis Prevención Ratón Sobrevivencia Sistema osteoarticular patología Enzima Hemopatía maligna Inmunoglobulinopatía Inmunopatología Linfoproliferativo síndrome Mammalia Rodentia Vertebrata
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B06 Immunopathology / 002B06D Immunodeficiencies. Immunoglobulinopathies / 002B06D02 Immunoglobulinopathies

Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B15 Diseases of the osteoarticular system / 002B15A Osteoporosis. Osteomalacia. Paget disease

Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B15 Diseases of the osteoarticular system / 002B15C Tumors of striated muscle and skeleton

Discipline
Immunopathology Osteoarticular pathology
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
18808121

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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