RXR-LXR heterodimer modulators for the potential treatment of dyslipidemia
- Author
- LAGU, Bharat1 ; PIO, Barbara1 ; LEBEDEV, Rimma1 ; YANG, Maria1 ; PELTON, Patricia D1
[1] Johnson and Johnson Pharmaceutical Research and Development, Cranbury, NJ 08869, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2007, Vol 17, Num 12, pp 3497-3503, 7 p
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- ABCA-1 Diabetes Dyslipidemia HDL LDL LXR RXR Triglycerides
- Keyword (fr)
- Agoniste Cholestérol Cinnamique acide dérivé Diabète Dyslipémie Fluor composé organique Hypolipémiant Hétérodimère In vivo Lactame Lipide Modulation Modèle Quinoléine dérivé Relation structure activité Rodentia Récepteur hormonal Récepteur nucléaire Récepteur rétinoïde RXR Synthèse chimique Thiazolidinedione dérivé Traitement Transduction signal Transporteur ABC Triglycéride Cinnamique acide(3-[1-éthyl-2-oxo-1,2,3,4-tétrahydro-4,4,6-triméthyl-7-quinolyl]-4-[2,2,2-trifluoroéthoxy]) Récepteur LXR Thiazolidine dérivé Endocrinopathie Mammalia Métabolisme pathologie Vertebrata
- Keyword (en)
- Agonist Cholesterol Cinnamic acid derivatives Diabetes mellitus Dyslipemia Organic fluorine compounds Antilipemic agent Heterodimer In vivo Lactam Lipids Modulation Models Quinoline derivatives Structure activity relation Rodentia Hormonal receptor Nuclear receptor RXR retinoid receptor Chemical synthesis Thiazolidinedione derivatives Treatment Signal transduction ABC transporter Triglyceride Liver X receptor Endocrinopathy Mammalia Metabolic diseases Vertebrata
- Keyword (es)
- Agonista Colesterol Cinámico ácido derivado Diabetes Dislipemia Hipolipemiante Heterodimero In vivo Lactamo Lípido Modulación Modelo Quinolina derivado Relación estructura actividad Rodentia Receptor hormonal Receptor nuclear Receptor retinoide RXR Síntesis química Tiazolidinediona derivado Tratamiento Transducción señal Transportador ABC Triglicérido Endocrinopatía Mammalia Metabolismo patología Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02N General and cellular metabolism. Vitamins
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 18811535
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2007.01.047 
https://dx.doi.org/10.1016/j.bmcl.2007.01.047
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