Targeting the methyl erythritol phosphate (MEP) pathway for novel antimalarial, antibacterial and herbicidal drug discovery : Inhibition of 1 -deoxy -D-xylulose -5 -phosphate reductoisomerase (DXR) enzyme
- Author
- SINGH, Nidhi1 ; CHEVE, Gweneal1 ; AVERY, Mitchell A1 2 3 ; MCCURDY, Christopher R1 3 4
[1] Department of Medicinal Chemistry and Laboratory for Applied Drug Design and Synthesis, School of Pharmacy, University of Mississippi, University, MS 38677-1848, United States
[2] Department of Chemistry and Biochemistry, University of Mississippi, University, MS 38677-1848, United States
[3] National Center for Natural Products Research, University of Mississippi, University, MS 38677-1848, United States
[4] Department of Pharmacology, School of Pharmacy, University of Mississippi, University, MS 38677-1848, United States - Source
Current pharmaceutical design. 2007, Vol 13, Num 11, pp 1161-1177, 17 p ; ref : 139 ref
- ISSN
- 1381-6128
- Scientific domain
- Pharmacology drugs
- Publisher
- Bentham Science, Hilversum
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- DXP reductoisomerase DXR FR900098 Isoprenoids MEP pathway fosmidomycin mevalonate
- Keyword (fr)
- Antibactérien Antipaludique Antiparasitaire Article synthèse Ciblage Cible Enzyme Fosmidomycine Herbicide Inhibiteur enzyme Inhibiteur Isoprénoïde Mécanisme action Médicament Phosphate Recherche développement 1-deoxy-D-xylulose-5-phosphate reductoisomerase Pesticide
- Keyword (en)
- Antibacterial agent Antimalarial Parasiticide Review Targeting Target Enzyme Fosmidomycin Herbicide Enzyme inhibitor Inhibitor Isoprenoid Mechanism of action Drug Phosphates Research and development 1-deoxy-D-xylulose-5-phosphate reductoisomerase Pesticides
- Keyword (es)
- Antibacteriano Antipalúdico Antiparasitario Artículo síntesis Blancado Blanco Enzima Fosmidomicina Herbicida Inhibidor enzima Inhibidor Isoprenoide Mecanismo acción Medicamento Fosfato Investigación desarrollo Plaguicida
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S02 Antibacterial agents
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S06 Antiparasitic agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 18835273
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.2174/138161207780618939 
https://dx.doi.org/10.2174/138161207780618939
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